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Pannexin 1 (PANX1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001670
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MBS2001670 is an antibody targeting PANX1. Also known as Polyclonal Antibody to Pannexin 1 (PANX1). Reactive in Rat. Host: Rabbit. More details

$220 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pannexin 1 (PANX1), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Pannexin 1 (PANX1)
Product Gene Name
anti-PANX1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.5mg/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: PANX1 (MBS2001670)
Immunogen: PANX1 (MBS2011561)
Matching Pairs
Unconjugated Antibody: PANX1 (MBS2001670)
APC-CY7 Conjugated Antibody: PANX1 (MBS2075515)
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3D Structure
ModBase 3D Structure for P60570
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant PANX1 (Ala77~Asp260 (Accession # P60570)) expressed in E.coli (MBS2011561).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-PANX1 antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).
Application Notes for anti-PANX1 antibody
Western blotting: 0.01-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-PANX1 antibody

Western Blot;
Sample: Recombinant PANX1, Rat.
Rabbit Anti-PANX1 Polyclonal Antibody – Cat# MBS2001670

Immunohistochemistry (IHC) of anti-PANX1 antibody

DAB staining on IHC-P;
Samples: Rat Cerebrum Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Rat PANX1 Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti- Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-PANX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001670

Immunohistochemistry (IHC) of anti-PANX1 antibody

DAB staining on IHC-P;
Samples: Rat Stomach Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Rat PANX1 Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-PANX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001670

Immunohistochemistry (IHC) of anti-PANX1 antibody

DAB staining on IHC-P;
Samples: Rat Cardiac Muscle Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Rat PANX1 Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-PANX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001670

Immunohistochemistry (IHC) of anti-PANX1 antibody

DAB staining on IHC-P;
Samples: Rat Skin Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Rat PANX1 Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-PANX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001670

Immunohistochemistry (IHC) of anti-PANX1 antibody

DAB staining on IHC-P;
Samples: Rat Liver Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Rat PANX1 Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-PANX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001670

Immunohistochemistry (IHC) of anti-PANX1 antibody

DAB staining on IHC-P;
Samples: Rat Intestine Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Rat PANX1 Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-PANX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001670

Other Notes

Small volumes of anti-PANX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PANX1. It may not necessarily be applicable to this product.

NCBI GI #
40786483
NCBI GeneID
315435
NCBI Accession #
NP_955429.1
UniProt Primary Accession #
P60570
UniProt Related Accession #
P60570
GenBank Nucleotide #
NM_199397.2
NCBI Official Full Name
pannexin-1 isoform a
NCBI Official Synonym Full Names
Pannexin 1
NCBI Official Symbol
Panx1
NCBI Official Synonym Symbols
px1
UniProt Protein Name
Pannexin-1
Protein Family
Pannexin
UniProt Gene Name
Panx1
UniProt Synonym Gene Names
Px1
NCBI Protein Information
pannexin-1

NCBI Summary for PANX1

The protein encoded by this gene is a plasma membrane protein that is a structural component of gap junctions. The encoded protein acts as a homodimer or as a heterodimer with other isoforms or proteins. Two additional variants have been found, and the isoforms expressed from them are found in the cytoplasm. It is thought that these two isoforms could attenuate the actions of the membrane-bound protein. [provided by RefSeq, Jul 2012]
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UniProt Comments for PANX1

PANX1: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8q12

Cellular Component: endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; gap junction; integral component of membrane; membrane; plasma membrane; protein complex

Molecular Function: actin binding; actin filament binding; calcium channel activity; channel activity; gap junction channel activity; gap junction hemi-channel activity; leak channel activity; protease binding; protein binding; protein heterodimerization activity; receptor binding

Biological Process: calcium ion transport; cation transport; cell-cell signaling; positive regulation of cytokine secretion; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; response to ATP; transmembrane transport
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Research Articles on PANX1

1. identify and characterize a metabotropic NMDAR signaling complex comprised of NMDARs, Panx1 channels and Src kinase.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PANX1 antibody

 Products by Pathway  Pathway Diagram
 Electric Transmission Across Gap Junctions Pathway antibodies  Electric Transmission Across Gap Junctions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 The NLRP3 Inflammasome Pathway antibodies  The NLRP3 Inflammasome Pathway Diagram
 Transmission Across Electrical Synapses Pathway antibodies  Transmission Across Electrical Synapses Pathway Diagram

Diseases associated with anti-PANX1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >13 publications with PANX1 and Inflammation
 Nerve Degeneration Antibodies  >3 publications with PANX1 and Nerve Degeneration
 Necrosis Antibodies  >3 publications with PANX1 and Necrosis
 Cardiovascular Diseases Antibodies  >2 publications with PANX1 and Cardiovascular Diseases
 Reperfusion Injury Antibodies  >2 publications with PANX1 and Reperfusion Injury
 Disease Models, Animal Antibodies  >2 publications with PANX1 and Disease Models, Animal
 Vascular Diseases Antibodies  >2 publications with PANX1 and Vascular Diseases
 Cerebrovascular Disorders Antibodies  >2 publications with PANX1 and Cerebrovascular Disorders
 Intestinal Diseases Antibodies  >1 publications with PANX1 and Intestinal Diseases
 Rheumatic Diseases Antibodies  >1 publications with PANX1 and Rheumatic Diseases

Organs/Tissues associated with anti-PANX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >41 publications with PANX1 and Brain
 Spinal Cord Antibodies  >2 publications with PANX1 and Spinal Cord
 Heart Antibodies  >2 publications with PANX1 and Heart
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