V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (RELA) Antibody – Rabbit Polyclonal

NFkB-p65: a subunit of NF-kappa-B transcription complex, which plays a crucial role in inflammatory and immune responses. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. P65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Three splice-variant isoforms have been identified.

Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 19 A|19 4.34 cM

Cellular Component: cytoplasm; cytosol; NF-kappaB complex; nuclear chromatin; nucleus; protein complex; transcription factor complex

Molecular Function: actinin binding; activating transcription factor binding; ankyrin repeat binding; chromatin binding; chromatin DNA binding; DNA binding; DNA binding transcription factor activity; enzyme binding; histone deacetylase binding; identical protein binding; NF-kappaB binding; phosphate binding; protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein N-terminus binding; sequence-specific DNA binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; transcription factor binding; transcription regulatory region DNA binding; ubiquitin protein ligase binding

Biological Process: cellular response to hydrogen peroxide; cellular response to interleukin-1; cellular response to interleukin-6; cellular response to nicotine; cellular response to peptide hormone stimulus; cellular response to tumor necrosis factor; cytokine-mediated signaling pathway; defense response; hair follicle development; inflammatory response; innate immune response; liver development; negative regulation of apoptosis; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of NIK/NF-kappaB signaling; negative regulation of protein catabolic process; negative regulation of protein sumoylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; NIK/NF-kappaB signaling; nucleotide-binding oligomerization domain containing 2 signaling pathway; organ morphogenesis; positive regulation of cell proliferation; positive regulation of chondrocyte differentiation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-12 biosynthetic process; positive regulation of miRNA metabolic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of Schwann cell differentiation; positive regulation of T cell receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of transcription, DNA-templated; regulation of DNA-templated transcription in response to stress; regulation of inflammatory response; regulation of NIK/NF-kappaB signaling; regulation of transcription, DNA-templated; response to bacterium; response to cytokine; response to muramyl dipeptide; response to muscle stretch; response to organic substance; response to UV-B; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway