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Antithrombin (AT) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001720
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MBS2001720 is an antibody targeting AT. Also known as Polyclonal Antibody to Antithrombin (AT). Reactive in Human, Mouse, Rat, Pig. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Antithrombin (AT), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Antithrombin (AT)
Product Gene Name
anti-AT antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- HGSPVDIC TAKPRDIPMN PMCIYRSPEK KATEDEGSEQ KIPEATNRRV WELSKANSRF ATTFYQHLAD SKNDNDNIFL SPLSISTAFA MTKLGACNDT LQQLMEVFKF DTISEKTSDQ IHFFFAKLNC RLYRKANKSS KLVSANRLFG DKSLTFNETY QDISELVYGA KLQPLDFKEN AEQSRAAINK WVSNKTEGRI TDVIPSEAIN ELTVLVLVNT IYFKGLWKSK FSPENTRKEL FYKADGESCS ASMMYQEGKF RYRRVAEGTQ VLELPFKGDD ITMVLILPKP EKSLAKVEKE LTPEVLQEWL DELEEMMLVV HMPRFRIEDG FSLKEQLQDM GLVDLFSPEK SKLPGIVAEG RDDLYVSDAF HKAFLEVNEE GSEAAASTAV VIAGRSLNPN RVTFKANRPF LVFIREVPLN TIIFMGRVAN PCVK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Pig
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against AT. It has been selected for its ability to recognize AT in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: AT (MBS2001720)
Biotin Conjugated Antibody: AT (MBS2001558)
Matching Pairs
Unconjugated Antibody: AT (MBS2001720)
Immunogen: AT (MBS2018656)
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Molecular Weight
52,602 Da
OMIM
L00185 Genomic DNA
3D Structure
ModBase 3D Structure for P01008
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant AT (His33~Lys464) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2064827
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-AT antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-AT antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-AT antibody

Western Blot: Sample: Human Lung lysate; Primary Ab: 1ug/ml Rabbit Anti-Human AT Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-AT Polyclonal Antibody – Cat# MBS2001720

Western Blot (WB) of anti-AT antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-AT Polyclonal Antibody, Western Blot (WB) – Cat# MBS2001720

Immunohistochemistry (IHC) of anti-AT antibody

DAB staining on IHC-P. Samples: Human Tissue)
Rabbit Anti-AT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001720

Other Notes

Small volumes of anti-AT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AT. It may not necessarily be applicable to this product.

NCBI GI #
4502261
NCBI GeneID
462
NCBI Accession #
NP_000479.1
UniProt Primary Accession #
P01008
UniProt Secondary Accession #
P78439; P78447; Q13815; Q5TC78; Q7KZ43; Q7KZ97; Q9UC78; B2R6P0
UniProt Related Accession #
P01008
GenBank Nucleotide #
NM_000488.3
NCBI Official Full Name
antithrombin-III
NCBI Official Synonym Full Names
serpin family C member 1
NCBI Official Symbol
SERPINC1
NCBI Official Synonym Symbols
AT3; AT3D; ATIII; THPH7
UniProt Protein Name
Antithrombin-III
UniProt Synonym Protein Names
Serpin C1
UniProt Gene Name
SERPINC1
UniProt Synonym Gene Names
AT3; ATIII
NCBI Protein Information
antithrombin-III

NCBI Summary for AT

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]
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UniProt Comments for AT

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Research Articles on AT

1. evaluation of serum proteins reveals that SERPINA1, SERPINA3 and SERPINC1 could be useful to discriminate healthy from colorectal carcinoma patients with a high sensitivity and specificity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AT antibody

 Reference Product  PubMed Publications
 PLG antibody  >2 publications with AT and PLG

Pathways associated with anti-AT antibody

 Products by Pathway  Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Glypican 1 Network Pathway antibodies  Glypican 1 Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-AT antibody

 Disease Name  Pubmed Publications
 Thrombosis Antibodies  >23 publications with AT and Thrombosis
 Antithrombin III Deficiency Antibodies  >22 publications with AT and Antithrombin III Deficiency
 Blood Coagulation Disorders Antibodies  >21 publications with AT and Blood Coagulation Disorders
 Vascular Diseases Antibodies  >19 publications with AT and Vascular Diseases
 Cardiovascular Diseases Antibodies  >19 publications with AT and Cardiovascular Diseases
 Venous Thrombosis Antibodies  >15 publications with AT and Venous Thrombosis
 Thromboembolism Antibodies  >9 publications with AT and Thromboembolism
 Venous Thromboembolism Antibodies  >6 publications with AT and Venous Thromboembolism
 Stroke Antibodies  >4 publications with AT and Stroke
 Liver Neoplasms Antibodies  >3 publications with AT and Liver Neoplasms

Organs/Tissues associated with anti-AT antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with AT and Liver
 Muscle Antibodies  >3 publications with AT and Muscle
 Mammary Gland Antibodies  >1 publications with AT and Mammary Gland
 Brain Antibodies  >1 publications with AT and Brain
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