Rabbit Anti-AGRP Polyclonal Antibody – Cat# MBS2001792

(Figure. Western Blot; Sample: Recombinant protein.)

Agouti Related Protein (AGRP) Antibody – Rabbit Polyclonal

Name: AGRP Antibody; Polyclonal; Rabbit; Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2001792
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2001792

MBS2001792 is an antibody targeting AGRP. Also known as Biotin-Linked Antibody to Agouti Related Protein (AGRP). Reactive in Mouse, Rat. Host: Rabbit. More details

$230 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Agouti Related Protein (AGRP), Polyclonal Antibody

Full Product Name

Biotin-Linked Antibody to Agouti Related Protein (AGRP)

Product Gene Name

anti-AGRP antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse, Rat

Form/Format

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

Purity/Purification

Affinity Chromatography

Concentration

500ug/ml (lot specific)

Specificity

The antibody is a rabbit polyclonal antibody raised against AGRP conjugated to biotin. It has been selected for its ability to recognize AGRP in immunohistochemical staining andwestern blotting.

Preparation and Storage

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Matching Pairs

Biotin Conjugated Antibody: AGRP (MBS2001792)
Immunogen: AGRP (MBS2010281)

Matching Pairs

Unconjugated Antibody: AGRP (MBS2001832)
Biotin Conjugated Antibody: AGRP (MBS2001792)

Molecular Weight

14,440 Da

Chromosome Location

Chromosome: 16; NC_000016.9 (67516474..67517716, complement). Location: 16q22

OMIM

601665

3D Structure

ModBase 3D Structure for O00253

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Product Categories/Family for anti-AGRP antibody

Biotin Antibody

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-AGRP antibody

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

Application Notes for anti-AGRP antibody

Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Other Notes

Small volumes of anti-AGRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AGRP. It may not necessarily be applicable to this product.

NCBI GI #

4501995

NCBI GeneID

181

NCBI Accession #

NP_001129.1

UniProt Primary Accession #

O00253

UniProt Secondary Accession #

O15459; Q2TBD9

UniProt Related Accession #

O00253

GenBank Nucleotide #

NM_001138.1

NCBI Official Full Name

agouti-related protein

NCBI Official Synonym Full Names

agouti related protein homolog (mouse)

NCBI Official Symbol

AGRP

NCBI Official Synonym Symbols

ART; AGRT; ASIP2

UniProt Protein Name

Agouti-related protein

Protein Family

Agouti-related protein

UniProt Gene Name

AGRP

UniProt Synonym Gene Names

AGRT; ART

UniProt Entry Name

AGRP_HUMAN

NCBI Protein Information

agouti-related protein

NCBI Summary for AGRP

This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

UniProt Comments for AGRP

AGRP: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. Genetic variations in AGRP may be a cause of obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Protein type: Secreted; Secreted, signal peptide; Hormone

Chromosomal Location of Human Ortholog: 16q22

Cellular Component: extracellular space; cell soma; Golgi lumen

Molecular Function: neuropeptide hormone activity; receptor binding

Biological Process: maternal process involved in pregnancy; hormone-mediated signaling; eating behavior; neuropeptide signaling pathway; photoperiodism; adult feeding behavior; feeding behavior; response to insulin stimulus

Disease: Obesity

Research Articles on AGRP

1. Data suggest that prolonged steady-state exercise/physical activity at moderate intensity elicits substantial increases in blood lactate and cortisol concentrations without a significant change in AgRP; study was pilot project involving men.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AGRP antibody

Reference Product	PubMed Publications
POMC antibody	>509 publications with AGRP and POMC
MC4R antibody	>121 publications with AGRP and MC4R
MC3R antibody	>56 publications with AGRP and MC3R
FOS antibody	>35 publications with AGRP and FOS
TRH antibody	>29 publications with AGRP and TRH
FOXO1 antibody	>11 publications with AGRP and FOXO1
LEP antibody	>6 publications with AGRP and LEP
SDC3 antibody	>3 publications with AGRP and SDC3
GHRL antibody	>3 publications with AGRP and GHRL

Pathways associated with anti-AGRP antibody

Products by Pathway	Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Syndecan-3-mediated Signaling Events Pathway antibodies	Syndecan-3-mediated Signaling Events Pathway Diagram

Diseases associated with anti-AGRP antibody

Disease Name	Pubmed Publications
Obesity Antibodies	>338 publications with AGRP and Obesity
Weight Gain Antibodies	>104 publications with AGRP and Weight Gain
Weight Loss Antibodies	>86 publications with AGRP and Weight Loss
Disease Models, Animal Antibodies	>53 publications with AGRP and Disease Models, Animal
Insulin Resistance Antibodies	>49 publications with AGRP and Insulin Resistance
Inflammation Antibodies	>23 publications with AGRP and Inflammation
Hyperglycemia Antibodies	>21 publications with AGRP and Hyperglycemia
Hyperinsulinism Antibodies	>20 publications with AGRP and Hyperinsulinism
Nervous System Diseases Antibodies	>16 publications with AGRP and Nervous System Diseases
Neoplasms Antibodies	>13 publications with AGRP and Neoplasms

Organs/Tissues associated with anti-AGRP antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>60 publications with AGRP and Connective Tissue
Kidney Antibodies	>17 publications with AGRP and Kidney
Lung Antibodies	>2 publications with AGRP and Lung