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Troponin I Type 3, Cardiac (TNNI3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001795
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MBS2001795 is an antibody targeting TNNI3. Also known as Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3). Reactive in Mouse, Human, Rat. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Troponin I Type 3, Cardiac (TNNI3), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Troponin I Type 3, Cardiac (TNNI3)
Product Gene Name
anti-TNNI3 antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- MADESSDAAG EPQPAPAPVR RRSSANYRAY ATEPHAKKKS KISASRKLQL KTLMLQIAKQ EMEREAEERR GEKGRVLRTR CQPLELDGLG FEELQDLCRQ LHARVDKVDE ERYDVEAKVT KNITEIADLT QKIYDLRGKF KRPTLRRVRI SADAMMQALL GTRAKESLDL RAHLKQVKKE DIEKENREVG DWRKNIDALS GMEGRKKKFE G
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against TNNI3. It has been selected for its ability to recognize TNNI3 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: TNNI3 (MBS2001795)
Biotin Conjugated Antibody: TNNI3 (MBS2006226)
Matching Pairs
Unconjugated Antibody: TNNI3 (MBS2001795)
Immunogen: TNNI3 (MBS2009012)
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Molecular Weight
24,259 Da
3D Structure
ModBase 3D Structure for P48787
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant TNNI3 (Met1~Gly211) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2042850
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-TNNI3 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-TNNI3 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-TNNI3 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-TNNI3 Polyclonal Antibody – Cat# MBS2001795

Immunohistochemistry (IHC) of anti-TNNI3 antibody

DABstainingonIHC-P.Samples:MouseTissue)
Rabbit Anti-TNNI3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001795

Other Notes

Small volumes of anti-TNNI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.

NCBI GI #
6678393
NCBI GeneID
21954
NCBI Accession #
NP_033432.1
UniProt Primary Accession #
P48787
UniProt Related Accession #
P48787
GenBank Nucleotide #
NM_009406.4
NCBI Official Full Name
troponin I, cardiac muscle
NCBI Official Synonym Full Names
troponin I, cardiac 3
NCBI Official Symbol
Tnni3
NCBI Official Synonym Symbols
Tn1; cTnI
UniProt Protein Name
Troponin I, cardiac muscle
UniProt Synonym Protein Names
Cardiac troponin I
Protein Family
Troponin
UniProt Gene Name
Tnni3
NCBI Protein Information
troponin I, cardiac muscle

UniProt Comments for TNNI3

TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family.

Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 7 A1|7 2.61 cM

Cellular Component: cardiac Troponin complex; contractile fiber; cytoplasm; myofibril; sarcomere; troponin complex

Molecular Function: actin binding; actin filament binding; calcium channel inhibitor activity; calcium-dependent protein binding; metal ion binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding

Biological Process: cardiac muscle contraction; cellular calcium ion homeostasis; heart contraction; heart development; negative regulation of ATPase activity; regulation of cardiac muscle contraction by calcium ion signaling; regulation of muscle contraction; regulation of smooth muscle contraction; regulation of systemic arterial blood pressure by ischemic conditions; skeletal muscle contraction; striated muscle contraction; vasculogenesis; ventricular cardiac muscle tissue morphogenesis
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Research Articles on TNNI3

1. Hyperphosphorylation of this serine199 in cTnI C terminus impacts heart function by depressing diastolic function at baseline and limiting systolic reserve under physiological stresses. Paradoxically, it preserves heart function after ischemia/reperfusion injury, potentially by decreasing proteolysis of cTnI.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNNI3 antibody

 Reference Product  PubMed Publications
 Tnnt2 antibody  >63 publications with TNNI3 and Tnnt2
 Mybpc3 antibody  >57 publications with TNNI3 and Mybpc3
 Tpm1 antibody  >39 publications with TNNI3 and Tpm1
 Myl2 antibody  >29 publications with TNNI3 and Myl2
 Myl3 antibody  >29 publications with TNNI3 and Myl3
 Tnnc1 antibody  >16 publications with TNNI3 and Tnnc1
 Myh6 antibody  >15 publications with TNNI3 and Myh6
 Tnnt3 antibody  >3 publications with TNNI3 and Tnnt3
 Tnnt1 antibody  >2 publications with TNNI3 and Tnnt1

Pathways associated with anti-TNNI3 antibody

 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Ion Homeostasis Pathway antibodies  Ion Homeostasis Pathway Diagram

Diseases associated with anti-TNNI3 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >89 publications with TNNI3 and Heart Diseases
 Cardiomyopathies Antibodies  >80 publications with TNNI3 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic, Familial Antibodies  >30 publications with TNNI3 and Cardiomyopathy, Hypertrophic, Familial
 Cardiomyopathy, Dilated Antibodies  >24 publications with TNNI3 and Cardiomyopathy, Dilated
 Cardiomyopathy, Restrictive Antibodies  >10 publications with TNNI3 and Cardiomyopathy, Restrictive
 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7 Antibodies  >9 publications with TNNI3 and CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7
 Nervous System Diseases Antibodies  >6 publications with TNNI3 and Nervous System Diseases
 Ventricular Dysfunction, Left Antibodies  >6 publications with TNNI3 and Ventricular Dysfunction, Left
 Fibrosis Antibodies  >6 publications with TNNI3 and Fibrosis
 Arrhythmias, Cardiac Antibodies  >5 publications with TNNI3 and Arrhythmias, Cardiac

Organs/Tissues associated with anti-TNNI3 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >72 publications with TNNI3 and Heart
 Muscle Antibodies  >68 publications with TNNI3 and Muscle
 Embryonic Tissue Antibodies  >5 publications with TNNI3 and Embryonic Tissue
 Lung Antibodies  >2 publications with TNNI3 and Lung
 Kidney Antibodies  >2 publications with TNNI3 and Kidney
 Skin Antibodies  >1 publications with TNNI3 and Skin
 Brain Antibodies  >1 publications with TNNI3 and Brain
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