Carbonic Anhydrase II (CA2) Antibody – Rabbit Polyclonal

CA2: Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala- His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO(3)). Esterase activity weakly reduced by cyanamide. N- hydroxyurea interfers with zinc binding and inhibit activity. Belongs to the alpha-carbonic anhydrase family.

Protein type: EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase

Chromosomal Location of Human Ortholog: 2q23

Cellular Component: apical part of cell; axon; basolateral plasma membrane; cytoplasm; cytosol; extracellular space; microvillus; myelin sheath; plasma membrane

Molecular Function: arylesterase activity; carbonate dehydratase activity; protein binding; zinc ion binding

Biological Process: carbon dioxide transport; kidney development; morphogenesis of an epithelium; odontogenesis of dentine-containing teeth; one-carbon metabolic process; osteoclast differentiation; positive regulation of bone resorption; positive regulation of cellular pH reduction; positive regulation of osteoclast differentiation; positive regulation of synaptic transmission, GABAergic; regulation of bone resorption; regulation of cellular pH; regulation of intracellular pH; response to estrogen; response to organic substance; response to pH; response to steroid hormone; response to zinc ion; secretion