Protein Kinase C Alpha (PKCa) Antibody – Rabbit Polyclonal

PKCA: an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic and receptors. Classical PKCs are calcium-dependent enzymes that are activated by phosphatidylserine, diacylglycerol and phorbol esters. Contains a pseudo-substrate autoinhibitory domain that binds to the catalytic domain preventing its activation in the absence of cofactors or activators.

Protein type: AGC group; Alpha subfamily; EC 2.7.11.13; Kinase, protein; Oncoprotein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 11 E1|11 70.8 cM

Cellular Component: apical part of cell; axon; cell soma; cytoplasm; cytosol; dendrite; endoplasmic reticulum; extracellular exosome; membrane; membrane raft; mitochondrion; neuron projection; nucleus; perinuclear region of cytoplasm; photoreceptor outer segment; plasma membrane; protein complex

Molecular Function: ATP binding; calcium-dependent protein kinase C activity; enzyme binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase C activity; protein serine/threonine kinase activity; transferase activity; zinc ion binding

Biological Process: angiogenesis; apoptosis; cell adhesion; cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; central nervous system neuron axonogenesis; chondrocyte differentiation; inactivation of MAPK activity; induction of positive chemotaxis; learning and/or memory; negative regulation of anion channel activity; negative regulation of cell proliferation; negative regulation of glucose import; negative regulation of heart contraction; negative regulation of insulin receptor signaling pathway; negative regulation of protein kinase activity; negative regulation of protein phosphorylation; negative regulation of translation; neutrophil chemotaxis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cardiac muscle hypertrophy; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of dense core granule biogenesis; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of exocytosis; positive regulation of inflammatory response; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of macrophage differentiation; positive regulation of mitotic cell cycle; positive regulation of protein phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of synaptogenesis; protein amino acid phosphorylation; protein autophosphorylation; regulation of muscle contraction; regulation of peptidyl-tyrosine phosphorylation; regulation of platelet aggregation; regulation of receptor-mediated endocytosis; regulation of response to osmotic stress; regulation of the force of heart contraction; response to estradiol; response to ethanol; response to reactive oxygen species