Glutathione S Transferase Pi (GSTp) Antibody – Rabbit Polyclonal

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

GSTP1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Homodimer. Interacts with CDK5. Belongs to the GST superfamily. Pi family.

Protein type: EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular space; ficolin-1-rich granule lumen; intracellular; mitochondrion; nucleus; plasma membrane; secretory granule lumen; vesicle

Molecular Function: drug binding; glutathione binding; glutathione peroxidase activity; glutathione transferase activity; JUN kinase binding; kinase regulator activity; nitric oxide binding; protein binding

Biological Process: cellular oxidant detoxification; cellular response to cell-matrix adhesion; cellular response to epidermal growth factor stimulus; cellular response to glucocorticoid stimulus; cellular response to insulin stimulus; cellular response to oxidative stress; central nervous system development; glutathione derivative biosynthetic process; glutathione metabolic process; linoleic acid metabolic process; negative regulation of acute inflammatory response; negative regulation of apoptosis; negative regulation of biosynthetic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fibroblast proliferation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of interleukin-1 beta production; negative regulation of JNK activity; negative regulation of MAP kinase activity; negative regulation of MAPKKK cascade; negative regulation of monocyte chemotactic protein-1 production; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of protein kinase activity; negative regulation of smooth muscle cell chemotaxis; negative regulation of stress-activated MAPK cascade; negative regulation of tumor necrosis factor production; negative regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of vascular smooth muscle cell proliferation; neutrophil degranulation; oligodendrocyte development; organ regeneration; positive regulation of superoxide anion generation; regulation of ERK1 and ERK2 cascade; regulation of stress-activated MAPK cascade; response to amino acid; response to estradiol; response to ethanol; response to L-ascorbic acid; response to reactive oxygen species; xenobiotic metabolic process