Cubilin (CUBN) Antibody – Rabbit Polyclonal

CUBN: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Defects in CUBN are a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1); also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS). RH-MGA1 is due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected.

Chromosomal Location of Human Ortholog: 17q12.3

Cellular Component: apical part of cell; apical plasma membrane; brush border; brush border membrane; clathrin-coated pit; cytoplasm; endocytic vesicle; endoplasmic reticulum; endosome; endosome membrane; Golgi apparatus; lysosomal lumen; lysosomal membrane; membrane; protein complex

Molecular Function: calcium ion binding; cobalamin binding; cobalamin transporter activity; drug binding; hemoglobin binding; identical protein binding; protein binding; protein homodimerization activity; receptor activity

Biological Process: cholesterol metabolic process; cobalamin transport; hemoglobin import; in utero embryonic development; lipoprotein transport; receptor-mediated endocytosis; response to nutrient; vitamin metabolic process