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CAV1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS200195

The identification of caveolin-1 (CAV1) as the main structural component of caveolae, together with the finding that CAV1 might serve as a molecular organizer for membrane multiprotein complexes involved in cellular traffic, endo-and transcytosis, cell… More details

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Product Overview

Online Datasheet in PDF
Product Name
CAV1, Monoclonal Antibody
Full Product Name
CAV1 antibody
Product Gene Name
anti-CAV1 antibody
Product Synonym Names
VIP 21; CAV; CAV 1; CAV1; caveolae protein 22 kD; caveolin 1 alpha isoform; caveolin 1 beta isoform; Caveolin 1 caveolae protein 22kDa; Caveolin1; cell growth-inhibiting protein 32; MSTP085; OTTHUMP00000025031; VIP 21; VIP21
Clonality
Monoclonal
Isotype
IgG2b, k
Clone Number
AT4C1
Host
Mouse
Species Reactivity
Human, Rat
Form/Format
Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
Purity/Purification
By protein-G affinity chromatography
Concentration
1mg/ml (lot specific)
Preparation and Storage
Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
17,023 Da
OMIM
Z18951 mRNA
3D Structure
ModBase 3D Structure for Q03135
Antigen Species
Human
Immunogen
Recombinant human CAV1 (1-104aa) purified from E. coli
Clone Note
CAV1 mAb, clone AT4C1, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PTS protein.

Product Categories/Family for anti-CAV1 antibody

Signal Transduction
Applications Tested/Suitable for anti-CAV1 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
Application Notes for anti-CAV1 antibody
WB: 1:250 ~ 1000.
Recommended starting dilution is 1:500 Application: ELISA, WB

Western Blot (WB) of anti-CAV1 antibody

The lysate (40ug) was resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CAV1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1. : Rat Brain lysate The lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CAV1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1. : Mouse Brain lysate Lane 2. : Mouse Heart cell lysate Lane 3. : A431 cell lysate
Mouse Anti-CAV1 Monoclonal Antibody – Cat# MBS200195

Immunofluorescence (IF) of anti-CAV1 antibody

ICC/IF analysis of CAV1 in A549 cells line, stained with DAPI (Blue) for nucleus staining and monoclonal anti-human CAV1 antibody (1:100) with goat anti-mouse IgG-Alexa fluor 488 conjugate (Green).
Mouse Anti-CAV1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS200195

Product References and Citations for anti-CAV1 antibody

Van Meer, G., et al. (2008) Nat Rev Mol Cell Biol. 9: 112-124; Todeschini, R.A. et al. (2008) Biochim Biophy Acta 1780: 421-433; Lajoie, P et al. (2007) J Cell Mol Med 11: 644-653

Other Notes

Small volumes of anti-CAV1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAV1 purchase

MBS200195 is an antibody targeting CAV1. Also known as CAV1 antibody. Reactive in Human, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CAV1. It may not necessarily be applicable to this product.

NCBI GI #
15451856
NCBI GeneID
857
NCBI Accession #
NP_001744
UniProt Primary Accession #
Q03135
UniProt Secondary Accession #
Q9UGP1; Q9UNG1; Q9UQH6
UniProt Related Accession #
Q03135
GenBank Nucleotide #
NM_001753.4
NCBI Official Full Name
caveolin-1 isoform alpha
NCBI Official Synonym Full Names
caveolin 1
NCBI Official Symbol
CAV1
NCBI Official Synonym Symbols
CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085
UniProt Protein Name
Caveolin-1
Protein Family
Caveolin
UniProt Gene Name
CAV1
UniProt Synonym Gene Names
CAV
NCBI Protein Information
caveolin-1

NCBI Summary for CAV1

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]
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UniProt Comments for CAV1

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).
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Research Articles on CAV1

1. Stromal, but not tumoural, caveolin-1 expression is significantly associated with survival in Asian women with triple-negative breast cancers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CAV1 antibody

 Reference Product  PubMed Publications
 CAV2 antibody  >212 publications with CAV1 and CAV2
 SRC antibody  >169 publications with CAV1 and SRC
 NOS3 antibody  >120 publications with CAV1 and NOS3
 EGFR antibody  >60 publications with CAV1 and EGFR
 FYN antibody  >27 publications with CAV1 and FYN
 AKT1 antibody  >21 publications with CAV1 and AKT1
 IRS1 antibody  >10 publications with CAV1 and IRS1
 INSR antibody  >3 publications with CAV1 and INSR

Pathways associated with anti-CAV1 antibody

 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway antibodies  Disassembly Of The Destruction Complex And Recruitment Of AXIN To The Membrane Pathway Diagram
 EGF/EGFR Signaling Pathway antibodies  EGF/EGFR Signaling Pathway Diagram

Diseases associated with anti-CAV1 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >194 publications with CAV1 and Heart Diseases
 Hypertension Antibodies  >141 publications with CAV1 and Hypertension
 Breast Neoplasms Antibodies  >113 publications with CAV1 and Breast Neoplasms
 Inflammation Antibodies  >101 publications with CAV1 and Inflammation
 Neoplasm Metastasis Antibodies  >88 publications with CAV1 and Neoplasm Metastasis
 Fibrosis Antibodies  >85 publications with CAV1 and Fibrosis
 Hypertrophy Antibodies  >70 publications with CAV1 and Hypertrophy
 Prostatic Neoplasms Antibodies  >69 publications with CAV1 and Prostatic Neoplasms
 Lung Neoplasms Antibodies  >66 publications with CAV1 and Lung Neoplasms
 Neoplasm Invasiveness Antibodies  >54 publications with CAV1 and Neoplasm Invasiveness

Organs/Tissues associated with anti-CAV1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >707 publications with CAV1 and Muscle
 Vascular Antibodies  >524 publications with CAV1 and Vascular
 Heart Antibodies  >454 publications with CAV1 and Heart
 Brain Antibodies  >409 publications with CAV1 and Brain
 Blood Antibodies  >369 publications with CAV1 and Blood
 Lung Antibodies  >245 publications with CAV1 and Lung
 Kidney Antibodies  >177 publications with CAV1 and Kidney
 Nerve Antibodies  >143 publications with CAV1 and Nerve
 Liver Antibodies  >125 publications with CAV1 and Liver
 Prostate Antibodies  >92 publications with CAV1 and Prostate
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