Rabbit Anti-PIGR Polyclonal Antibody – Cat# MBS2001987

(Figure. Western Blot; Sample: Recombinant protein.)

Polymeric Immunoglobulin Receptor (PIGR) Antibody – Rabbit Polyclonal

Name: PIGR Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2001987
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2001987

MBS2001987 is an antibody targeting PIGR. Also known as Biotin-Linked Antibody to Polymeric Immunoglobulin Receptor (PIGR). Reactive in Mouse. Host: Rabbit. More details

$220 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Polymeric Immunoglobulin Receptor (PIGR), Polyclonal Antibody

Full Product Name

Biotin-Linked Antibody to Polymeric Immunoglobulin Receptor (PIGR)

Product Gene Name

anti-PIGR antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as solution form in 0.01 M PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.

Purity/Purification

Antigen-specific Affinity Chromatography.

Concentration

0.46mg/ml (lot specific)

Preparation and Storage

Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Matching Pairs

Biotin Conjugated Antibody: PIGR (MBS2001987)
Immunogen: PIGR (MBS2009249)

Matching Pairs

Unconjugated Antibody: PIGR (MBS2004792)
Biotin Conjugated Antibody: PIGR (MBS2001987)

Chromosome Location

Chromosome: 1; NC_000001.10 (207101867..207119814, complement). Location: 1q31-q41

OMIM

173880

3D Structure

ModBase 3D Structure for P01833

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Source

Antibody labeling

Label

Biotin

Unconjugated Antibody

MBS2004792

Traits

Liquid

Immunogen

Recombinant PIGR (Ser135~Val237) expressed in E.coli (MBS2009249).

Product Categories/Family for anti-PIGR antibody

Biotin Antibody

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-PIGR antibody

Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).

Application Notes for anti-PIGR antibody

Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user

Other Notes

Small volumes of anti-PIGR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PIGR. It may not necessarily be applicable to this product.

NCBI GI #

31377806

NCBI GeneID

5284

NCBI Accession #

NP_002635.2

UniProt Primary Accession #

P01833

UniProt Secondary Accession #

Q68D81; Q8IZY7

UniProt Related Accession #

P01833

GenBank Nucleotide #

NM_002644.3

NCBI Official Full Name

polymeric immunoglobulin receptor

NCBI Official Synonym Full Names

polymeric immunoglobulin receptor

NCBI Official Symbol

PIGR

UniProt Protein Name

Polymeric immunoglobulin receptor

UniProt Synonym Protein Names

Hepatocellular carcinoma-associated protein TB6

Protein Family

Polymeric immunoglobulin receptor

UniProt Gene Name

PIGR

UniProt Synonym Gene Names

PIgR

UniProt Entry Name

PIGR_HUMAN

NCBI Protein Information

polymeric immunoglobulin receptor; poly-Ig receptor; hepatocellular carcinoma associated protein TB6; hepatocellular carcinoma-associated protein TB6

NCBI Summary for PIGR

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]

UniProt Comments for PIGR

PIGR: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

Protein type: Receptor, misc.; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q31-q41

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; receptor complex

Molecular Function: polymeric immunoglobulin receptor activity

Biological Process: epidermal growth factor receptor signaling pathway; retinal homeostasis; detection of chemical stimulus involved in sensory perception of bitter taste; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; receptor clustering

Disease: Iga Nephropathy, Susceptibility To, 1

Research Articles on PIGR

1. Results indicated that the polymeric immunoglobulin receptor (pIgR) can be divided into several functionally distinct regions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PIGR antibody

Reference Product	PubMed Publications
PIGA antibody	>42 publications with PIGR and PIGA
STAT6 antibody	>3 publications with PIGR and STAT6
RAB3B antibody	>1 publications with PIGR and RAB3B

Pathways associated with anti-PIGR antibody

Products by Pathway	Pathway Diagram
IL4-mediated Signaling Events Pathway antibodies	IL4-mediated Signaling Events Pathway Diagram
Integrated Breast Cancer Pathway antibodies	Integrated Breast Cancer Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram

Diseases associated with anti-PIGR antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>32 publications with PIGR and Inflammation
Neoplasms Antibodies	>26 publications with PIGR and Neoplasms
Necrosis Antibodies	>26 publications with PIGR and Necrosis
Kidney Diseases Antibodies	>11 publications with PIGR and Kidney Diseases
Adenocarcinoma Antibodies	>11 publications with PIGR and Adenocarcinoma
Liver Diseases Antibodies	>8 publications with PIGR and Liver Diseases
Glomerulonephritis, IGA Antibodies	>6 publications with PIGR and Glomerulonephritis, IGA
Carcinoma, Hepatocellular Antibodies	>3 publications with PIGR and Carcinoma, Hepatocellular
Cell Transformation, Neoplastic Antibodies	>3 publications with PIGR and Cell Transformation, Neoplastic
Cholestasis Antibodies	>3 publications with PIGR and Cholestasis

Organs/Tissues associated with anti-PIGR antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>77 publications with PIGR and Intestine
Kidney Antibodies	>59 publications with PIGR and Kidney
Liver Antibodies	>43 publications with PIGR and Liver
Lung Antibodies	>30 publications with PIGR and Lung
Mammary Gland Antibodies	>16 publications with PIGR and Mammary Gland
Muscle Antibodies	>7 publications with PIGR and Muscle
Brain Antibodies	>7 publications with PIGR and Brain
Uterus Antibodies	>6 publications with PIGR and Uterus
Stomach Antibodies	>5 publications with PIGR and Stomach
Skin Antibodies	>5 publications with PIGR and Skin