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Lysyl Oxidase (LOX) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001999
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MBS2001999 is an antibody targeting LOX. Also known as Polyclonal Antibody to Lysyl Oxidase (LOX). Reactive in Mouse, Human, Rat. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lysyl Oxidase (LOX), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Lysyl Oxidase (LOX)
Product Gene Name
anti-LOX antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGS-P DLV PDPYYIQAST YVQKMSMYNL RCAAEENCLA SSAYRADVRD YDHRVLLRFP QRVKNQGTSD FLPSRPRYSW EWHSCHQHYH SMDEFSHYDL LDANTQRRVA EGHKASFCLE DTSCDYGYHR RFACTAHTQG LSPGCYDTYA ADIDCQWIDI TDVQPGNYIL KVSVNPSYLV PESDYTNNVV RCDIRYTGHH AYASGCTISP Y
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
0.7mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against LOX. It has been selected for its ability to recognize LOX in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: LOX (MBS2001999)
Biotin Conjugated Antibody: LOX (MBS2006400)
Matching Pairs
Unconjugated Antibody: LOX (MBS2001999)
Immunogen: LOX (MBS2012304)
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Molecular Weight
46,701 Da
3D Structure
ModBase 3D Structure for P28301
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant LOX (Pro207-Tyr411) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2066831
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-LOX antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-LOX antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-LOX antibody

Western Blot: Sample: Recombinant LOX, Mouse.
Rabbit Anti-LOX Polyclonal Antibody – Cat# MBS2001999

Immunohistochemistry (IHC) of anti-LOX antibody

DAB staining on IHC-P; Samples: Mouse Stomach Tissue.
Rabbit Anti-LOX Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001999

Immunohistochemistry (IHC) of anti-LOX antibody

DAB staining on IHC-P; Samples: Mouse Pancreas Tissue.
Rabbit Anti-LOX Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001999

Other Notes

Small volumes of anti-LOX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LOX. It may not necessarily be applicable to this product.

NCBI GI #
555943929
NCBI GeneID
16948
NCBI Accession #
NP_001273110.1
UniProt Primary Accession #
P28301
UniProt Related Accession #
P28301
GenBank Nucleotide #
NM_001286181.1
NCBI Official Full Name
protein-lysine 6-oxidase preproprotein
NCBI Official Synonym Full Names
lysyl oxidase
NCBI Official Symbol
Lox
NCBI Official Synonym Symbols
rrg; TSC-160; AI893619
UniProt Protein Name
Protein-lysine 6-oxidase
UniProt Synonym Protein Names
Lysyl oxidase; Ras excision protein
Protein Family
Linoleate 9/13-lipoxygenase
UniProt Gene Name
Lox
UniProt Synonym Gene Names
Rrg
NCBI Protein Information
protein-lysine 6-oxidase

NCBI Summary for LOX

This gene encodes a precursor protein that belongs to the lysyl oxidase family of proteins. The secreted proprotein is proteolytically processed to an active mature peptide and a propeptide. This propeptide is thought to function in tumor suppression by inhibiting the Ras signaling pathway. The active enzyme plays a role in cross-linking of collagen and elastin and is essential for development of cardiovascular and respiratory systems, and development of skin and connective tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
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UniProt Comments for LOX

LOX: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Belongs to the lysyl oxidase family.

Protein type: EC 1.4.3.13; Oxidoreductase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 18 D1|18 28.22 cM

Cellular Component: collagen; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrix

Molecular Function: copper ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor; protein binding; protein-lysine 6-oxidase activity

Biological Process: blood vessel development; blood vessel morphogenesis; collagen fibril organization; elastic fiber assembly; heart development; lung development; response to hormone; response to steroid hormone; wound healing
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Research Articles on LOX

1. Data show that LOX-PP enhances adipogenesis at least partially through inhibition of FGF-2 receptor signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LOX antibody

 Reference Product  PubMed Publications
 Loxl1 antibody  >64 publications with LOX and Loxl1
 Src antibody  >37 publications with LOX and Src
 Bmp1 antibody  >8 publications with LOX and Bmp1
 Fbln5 antibody  >8 publications with LOX and Fbln5
 Eln antibody  >3 publications with LOX and Eln
 Snai1 antibody  >2 publications with LOX and Snai1
 Efemp2 antibody  >2 publications with LOX and Efemp2

Pathways associated with anti-LOX antibody

 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Crosslinking Of Collagen Fibrils Pathway antibodies  Crosslinking Of Collagen Fibrils Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram

Diseases associated with anti-LOX antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >736 publications with LOX and Inflammation
 Cardiovascular Diseases Antibodies  >675 publications with LOX and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >459 publications with LOX and Disease Models, Animal
 Necrosis Antibodies  >271 publications with LOX and Necrosis
 Heart Diseases Antibodies  >210 publications with LOX and Heart Diseases
 Lung Diseases Antibodies  >195 publications with LOX and Lung Diseases
 Fibrosis Antibodies  >171 publications with LOX and Fibrosis
 Neoplasms, Experimental Antibodies  >167 publications with LOX and Neoplasms, Experimental
 Hypertension Antibodies  >165 publications with LOX and Hypertension
 Lung Neoplasms Antibodies  >137 publications with LOX and Lung Neoplasms

Organs/Tissues associated with anti-LOX antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >452 publications with LOX and Muscle
 Brain Antibodies  >428 publications with LOX and Brain
 Artery Antibodies  >389 publications with LOX and Artery
 Lung Antibodies  >330 publications with LOX and Lung
 Heart Antibodies  >304 publications with LOX and Heart
 Liver Antibodies  >288 publications with LOX and Liver
 Bone Antibodies  >266 publications with LOX and Bone
 Skin Antibodies  >195 publications with LOX and Skin
 Kidney Antibodies  >189 publications with LOX and Kidney
 Embryonic Tissue Antibodies  >169 publications with LOX and Embryonic Tissue
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