Rabbit Anti-PYGM Polyclonal Antibody – Cat# MBS2002007

Glycogen Phosphorylase, Muscle (PYGM) Antibody – Rabbit Polyclonal

Name: PYGM Antibody; Polyclonal; Rabbit; Mouse/Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS2002007
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2002007

MBS2002007 is an antibody targeting PYGM. Also known as Biotin-Linked Antibody to Glycogen Phosphorylase, Muscle (PYGM). Reactive in Mouse, Human, Rat. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glycogen Phosphorylase, Muscle (PYGM), Polyclonal Antibody

Full Product Name

Biotin-Linked Antibody to Glycogen Phosphorylase, Muscle (PYGM)

Product Gene Name

anti-PYGM antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse, Human, Rat

Form/Format

Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.

Purity/Purification

Affinity Chromatography

Concentration

500ug/ml (lot specific)

Specificity

The antibody is a rabbit polyclonal antibody raised against PYGM conjugated to biotin. It has been selected for its ability to recognize PYGM in immunohistochemical staining andwestern blotting.

Preparation and Storage

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Matching Pairs

Biotin Conjugated Antibody: PYGM (MBS2002007)
Immunogen: PYGM (MBS2011599)

Matching Pairs

Unconjugated Antibody: PYGM (MBS2002939)
Biotin Conjugated Antibody: PYGM (MBS2002007)

Molecular Weight

97,092 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (64513861..64528187, complement). Location: 11q12-q13.2

OMIM

232600

3D Structure

ModBase 3D Structure for P11217

Supply Chain Verification

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Product Categories/Family for anti-PYGM antibody

Biotin Antibody

ISO Certification

Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.

Applications Tested/Suitable for anti-PYGM antibody

Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)

Application Notes for anti-PYGM antibody

Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Other Notes

Small volumes of anti-PYGM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PYGM. It may not necessarily be applicable to this product.

NCBI GI #

257900462

NCBI GeneID

5837

NCBI Accession #

NP_001158188.1

UniProt Primary Accession #

P11217

UniProt Secondary Accession #

A0AVK1; A6NDY6

UniProt Related Accession #

P11217

GenBank Nucleotide #

NM_001164716.1

NCBI Official Full Name

glycogen phosphorylase, muscle form isoform 2

NCBI Official Synonym Full Names

phosphorylase, glycogen, muscle

NCBI Official Symbol

PYGM

UniProt Protein Name

Glycogen phosphorylase, muscle form

UniProt Synonym Protein Names

Myophosphorylase

Protein Family

Glycogen phosphorylase

UniProt Gene Name

PYGM

UniProt Entry Name

PYGM_HUMAN

NCBI Protein Information

glycogen phosphorylase, muscle form; myophosphorylase

NCBI Summary for PYGM

This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]

UniProt Comments for PYGM

PYGM: an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Dimers associate into a tetramer to form the enzymatically active phosphorylase A. Phosphorylation of Ser-14 converts phosphorylase B (unphosphorylated) to phosphorylase A.

Protein type: Carbohydrate Metabolism - starch and sucrose; Phosphorylase; Transferase; EC 2.4.1.1; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 11q12-q13.2

Cellular Component: cytosol

Molecular Function: glycogen phosphorylase activity; nucleotide binding; pyridoxal phosphate binding

Biological Process: glycogen metabolic process; glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis

Disease: Glycogen Storage Disease V

Research Articles on PYGM

1. a novel mutation, in the PYGM gene c.632delG, in three unrelated families of Jewish descent originating from the Caucasus region

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PYGM antibody

Reference Product	PubMed Publications
FAU antibody	>4 publications with PYGM and FAU
PHKB antibody	>3 publications with PYGM and PHKB
GBE1 antibody	>2 publications with PYGM and GBE1
PHKA1 antibody	>2 publications with PYGM and PHKA1
PFKM antibody	>1 publications with PYGM and PFKM
PHKG1 antibody	>1 publications with PYGM and PHKG1

Pathways associated with anti-PYGM antibody

Products by Pathway	Pathway Diagram
Glucose Metabolism Pathway antibodies	Glucose Metabolism Pathway Diagram
Glycogen Metabolism Pathway antibodies	Glycogen Metabolism Pathway Diagram
Glycogen Breakdown (glycogenolysis) Pathway antibodies	Glycogen Breakdown (glycogenolysis) Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Carbohydrates Pathway antibodies	Metabolism Of Carbohydrates Pathway Diagram
Starch And Sucrose Metabolism Pathway antibodies	Starch And Sucrose Metabolism Pathway Diagram
Starch And Sucrose Metabolism Pathway antibodies	Starch And Sucrose Metabolism Pathway Diagram

Diseases associated with anti-PYGM antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>64 publications with PYGM and Neoplasms
Glycogen Storage Disease Type V Antibodies	>57 publications with PYGM and Glycogen Storage Disease Type V
Nervous System Diseases Antibodies	>22 publications with PYGM and Nervous System Diseases
Adenocarcinoma Antibodies	>15 publications with PYGM and Adenocarcinoma
Hyperplasia Antibodies	>10 publications with PYGM and Hyperplasia
Muscular Diseases Antibodies	>8 publications with PYGM and Muscular Diseases
Breast Neoplasms Antibodies	>6 publications with PYGM and Breast Neoplasms
Lung Neoplasms Antibodies	>6 publications with PYGM and Lung Neoplasms
Carcinoma, Squamous Cell Antibodies	>3 publications with PYGM and Carcinoma, Squamous Cell
Skin Neoplasms Antibodies	>2 publications with PYGM and Skin Neoplasms

Organs/Tissues associated with anti-PYGM antibody

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>83 publications with PYGM and Muscle
Blood Antibodies	>16 publications with PYGM and Blood
Pancreas Antibodies	>9 publications with PYGM and Pancreas
Liver Antibodies	>8 publications with PYGM and Liver
Lung Antibodies	>8 publications with PYGM and Lung
Eye Antibodies	>4 publications with PYGM and Eye
Brain Antibodies	>4 publications with PYGM and Brain
Heart Antibodies	>4 publications with PYGM and Heart
Nerve Antibodies	>3 publications with PYGM and Nerve
Uterus Antibodies	>1 publications with PYGM and Uterus