Rala Binding Protein 1 (RALBP1) Antibody – Rabbit Polyclonal

RALBP1: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin. Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis. Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.

Protein type: GAP; GAP, Rac/Rho

Chromosomal Location of Human Ortholog: 9q37

Cellular Component: cytosol; membrane; neuron projection; plasma membrane; spindle pole

Molecular Function: ATPase activity; GTPase activator activity; protein binding; Rac GTPase binding; Ral GTPase binding; transmembrane transporter activity

Biological Process: cell division; endocytosis; mitotic spindle organization and biogenesis; negative regulation of smooth muscle cell proliferation; positive regulation of GTPase activity; regulation of GTPase activity; signal transduction; small GTPase mediated signal transduction; transmembrane transport; transport