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Macrophage Inflammatory Protein 1 Alpha (MIP1a) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002052
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MBS2002052 is an antibody targeting MIP1a. Also known as Polyclonal Antibody to Macrophage Inflammatory Protein 1 Alpha (MIP1a). Reactive in Mouse, Rat. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Macrophage Inflammatory Protein 1 Alpha (MIP1a), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Macrophage Inflammatory Protein 1 Alpha (MIP1a)
Product Gene Name
anti-MIP1a antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- APYGADT PTACCFSYSR KIPRQFIVDY FETSSLCSQP GVIFLTKRNR QICADSKETW VQEYITDLEL NA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
0.41mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against MIP1a. It has been selected for its ability to recognize MIP1a in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: MIP1a (MBS2002052)
Biotin Conjugated Antibody: MIP1a (MBS2004577)
Matching Pairs
Unconjugated Antibody: MIP1a (MBS2002052)
Immunogen: MIP1a (MBS2029961)
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Molecular Weight
10,345 Da
3D Structure
ModBase 3D Structure for P10855
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant MIP1a (Ala24~Ala92) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2037557
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-MIP1a antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-MIP1a antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-MIP1a antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-MIP1a Polyclonal Antibody – Cat# MBS2002052

Immunohistochemistry (IHC) of anti-MIP1a antibody

DAB staining on fromalin fixed paraffin-embedded Liver tissue)
Rabbit Anti-MIP1a Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002052

Other Notes

Small volumes of anti-MIP1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP1a. It may not necessarily be applicable to this product.

NCBI GI #
6755432
NCBI GeneID
20302
NCBI Accession #
NP_035467.1
UniProt Primary Accession #
P10855
UniProt Secondary Accession #
P14096
UniProt Related Accession #
P10855
GenBank Nucleotide #
NM_011337.2
NCBI Official Full Name
C-C motif chemokine 3
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 3
NCBI Official Symbol
Ccl3
NCBI Official Synonym Symbols
Mip1a; Scya3; G0S19-1; AI323804; MIP1-(a); LD78alpha; MIP-1alpha; MIP1-alpha
UniProt Protein Name
C-C motif chemokine 3
UniProt Synonym Protein Names
Heparin-binding chemotaxis protein; L2G25B; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; SIS-alpha; Small-inducible cytokine A3; TY-5
Protein Family
B-box domain protein
UniProt Gene Name
Ccl3
UniProt Synonym Gene Names
Mip1a; Scya3; MIP-1-alpha
NCBI Protein Information
C-C motif chemokine 3

UniProt Comments for MIP1a

CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11 C|11 51.04 cM

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR chemokine receptor binding; chemokine activity; cytokine activity; protein binding

Biological Process: astrocyte cell migration; chemotaxis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; immune response; inflammatory response; leukocyte chemotaxis; lymphocyte chemotaxis; macrophage chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of inflammatory response; positive regulation of interleukin-1 beta secretion; positive regulation of neuron apoptotic process; positive regulation of osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of cell shape
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Research Articles on MIP1a

1. CCL3 plays a significant role in the clearance of infection and resolution of otitis media inflammation and contributes to mucosal host defense of the nasopharyngeal niche, a reservoir for middle ear and upper respiratory infections.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MIP1a antibody

 Products by Pathway  Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram

Diseases associated with anti-MIP1a antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >893 publications with MIP1a and Inflammation
 Necrosis Antibodies  >506 publications with MIP1a and Necrosis
 Disease Models, Animal Antibodies  >314 publications with MIP1a and Disease Models, Animal
 Lung Diseases Antibodies  >238 publications with MIP1a and Lung Diseases
 HIV Infections Antibodies  >188 publications with MIP1a and HIV Infections
 Cardiovascular Diseases Antibodies  >173 publications with MIP1a and Cardiovascular Diseases
 Hypersensitivity Antibodies  >105 publications with MIP1a and Hypersensitivity
 Liver Diseases Antibodies  >95 publications with MIP1a and Liver Diseases
 Fibrosis Antibodies  >79 publications with MIP1a and Fibrosis
 Pneumonia Antibodies  >72 publications with MIP1a and Pneumonia

Organs/Tissues associated with anti-MIP1a antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1553 publications with MIP1a and Blood
 Bone Antibodies  >291 publications with MIP1a and Bone
 Brain Antibodies  >257 publications with MIP1a and Brain
 Bone Marrow Antibodies  >208 publications with MIP1a and Bone Marrow
 Spleen Antibodies  >111 publications with MIP1a and Spleen
 Skin Antibodies  >101 publications with MIP1a and Skin
 Lymph Node Antibodies  >94 publications with MIP1a and Lymph Node
 Joint Antibodies  >74 publications with MIP1a and Joint
 Embryonic Tissue Antibodies  >30 publications with MIP1a and Embryonic Tissue
 Thymus Antibodies  >21 publications with MIP1a and Thymus
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