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Heparan Sulfate Proteoglycan (HSPG) Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002056
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MBS2002056 is an antibody targeting HSPG. Also known as Polyclonal Antibody to Heparan Sulfate Proteoglycan (HSPG). Reactive in Human. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Heparan Sulfate Proteoglycan (HSPG), Antibody
Full Product Name
Polyclonal Antibody to Heparan Sulfate Proteoglycan (HSPG)
Product Gene Name
anti-HSPG antibody
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.5mg/ml (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: HSPG (MBS2002056)
Biotin Conjugated Antibody: HSPG (MBS2004505)
Matching Pairs
Unconjugated Antibody: HSPG (MBS2002056)
Immunogen: HSPG (MBS2009846)
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OMIM
J04621 mRNA
3D Structure
ModBase 3D Structure for P34741
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant HSPG (Glu19~Glu144) expressed in E.coli ( MBS2009846 ).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-HSPG antibody
Western Blot (WB); Immunohistochemistry (IHC); Immunocytochemistry (ICC); Immunoprecipitation (IP).
Application Notes for anti-HSPG antibody
Western blotting: 0.01-2ug/mL;
Immunohistochemistry: 5-20ug/mL;
Immunocytochemistry: 5-20ug/mL;
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-HSPG antibody

Western Blot;
Sample: Recombinant HSPG, Human.
Rabbit Anti-HSPG Antibody – Cat# MBS2002056

Western Blot (WB) of anti-HSPG antibody

Western Blot;
Sample:
Lane 1: Human Serum
Lane 2: Hela cell lysate
Lane 3: HepG2 cell lysateu
Primary Ab: 1ug/ml Rabbit Anti-Human HSPG Antibody
Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047 )
Rabbit Anti-HSPG Antibody, Western Blot (WB) – Cat# MBS2002056

Immunohistochemistry (IHC) of anti-HSPG antibody

DAB staining on IHC-P;
Samples: Human Prostate Tissue;
Primary Ab: 20ug/ml Rabbit Anti-Human HSPG Antibody
Second Ab: 2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047 )
Rabbit Anti-HSPG Antibody, Immunohistochemistry (IHC) – Cat# MBS2002056

Other Notes

Small volumes of anti-HSPG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPG. It may not necessarily be applicable to this product.

NCBI GI #
40548378
NCBI GeneID
6383
NCBI Accession #
NP_002989.2
UniProt Primary Accession #
P34741
UniProt Secondary Accession #
Q6PIS6; Q9H6V1; B3KQA3
UniProt Related Accession #
P34741
GenBank Nucleotide #
NM_002998.3
NCBI Official Full Name
syndecan-2
NCBI Official Synonym Full Names
syndecan 2
NCBI Official Symbol
SDC2
NCBI Official Synonym Symbols
HSPG; CD362; HSPG1; SYND2
UniProt Protein Name
Syndecan-2
UniProt Synonym Protein Names
Fibroglycan; Heparan sulfate proteoglycan core protein; HSPG; CD_antigen: CD362
UniProt Gene Name
SDC2
UniProt Synonym Gene Names
HSPG1; SYND2; HSPG
NCBI Protein Information
syndecan-2

NCBI Summary for HSPG

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
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UniProt Comments for HSPG

syndecan-2: a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Preferentially expressed in cells of mesenchymal origin. Is tyrosine phosphorylated and forms a complex with EphB2 in mouse brain. Plays a role in mediating adhesion and proliferation of colon carcinoma cells.

Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: cell surface; endoplasmic reticulum lumen; extracellular matrix; Golgi lumen; integral component of membrane; lysosomal lumen; plasma membrane

Molecular Function: identical protein binding; PDZ domain binding; protein binding

Biological Process: bioluminescence; cell migration; cellular protein metabolic process; dendrite morphogenesis; ephrin receptor signaling pathway; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; leukocyte migration; post-translational protein modification; regulation of dendrite morphogenesis; retinoid metabolic process
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Research Articles on HSPG

1. data suggest that syndecan-2 induces extracellular shedding of E-cadherin and supports the acquisition of a fibroblast-like morphology by regulating MMP-7 expression in a colon cancer cell line

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSPG antibody

 Reference Product  PubMed Publications
 SDC1 antibody  >33 publications with HSPG and SDC1
 CASK antibody  >6 publications with HSPG and CASK
 TGFB1 antibody  >5 publications with HSPG and TGFB1
 SDCBP antibody  >4 publications with HSPG and SDCBP
 EPHB2 antibody  >2 publications with HSPG and EPHB2
 GNB2L1 antibody  >1 publications with HSPG and GNB2L1
 FN1 antibody  >1 publications with HSPG and FN1
 CSF2 antibody  >1 publications with HSPG and CSF2
 TRAPPC4 antibody  >1 publications with HSPG and TRAPPC4

Pathways associated with anti-HSPG antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram

Diseases associated with anti-HSPG antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >10 publications with HSPG and Necrosis
 Neoplasms, Experimental Antibodies  >8 publications with HSPG and Neoplasms, Experimental
 Brain Diseases Antibodies  >6 publications with HSPG and Brain Diseases
 Nervous System Diseases Antibodies  >6 publications with HSPG and Nervous System Diseases
 Inflammation Antibodies  >5 publications with HSPG and Inflammation
 Breast Neoplasms Antibodies  >4 publications with HSPG and Breast Neoplasms
 Fibrosis Antibodies  >3 publications with HSPG and Fibrosis
 Heart Diseases Antibodies  >3 publications with HSPG and Heart Diseases
 Cardiovascular Diseases Antibodies  >3 publications with HSPG and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with HSPG and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-HSPG antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with HSPG and Blood
 Brain Antibodies  >18 publications with HSPG and Brain
 Vascular Antibodies  >16 publications with HSPG and Vascular
 Muscle Antibodies  >14 publications with HSPG and Muscle
 Bone Antibodies  >14 publications with HSPG and Bone
 Embryonic Tissue Antibodies  >8 publications with HSPG and Embryonic Tissue
 Lung Antibodies  >7 publications with HSPG and Lung
 Liver Antibodies  >7 publications with HSPG and Liver
 Mouth Antibodies  >7 publications with HSPG and Mouth
 Skin Antibodies  >6 publications with HSPG and Skin
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