Transferrin (TRF) Antibody – Rabbit Polyclonal

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q32

Cellular Component: apical plasma membrane; basal plasma membrane; basement membrane; cell surface; clathrin-coated pit; cytoplasmic vesicle; early endosome; endocytic vesicle; endosome; extracellular region; extracellular space; extrinsic to external side of plasma membrane; integral component of membrane; late endosome; membrane; perinuclear region of cytoplasm; recycling endosome; vesicle

Molecular Function: ferric iron binding; ferric iron transmembrane transporter activity; ferrous iron binding; GTP binding

Biological Process: actin filament organization; activation of JNK activity; acute-phase response; apoptosis; cellular iron ion homeostasis; ferric iron transport; iron ion transport; osteoclast differentiation; positive regulation of bone resorption; positive regulation of myelination; positive regulation of phosphorylation; positive regulation of receptor-mediated endocytosis; positive regulation of transcription, DNA-templated; response to hypoxia; response to lead ion; response to organic cyclic compound; retinal homeostasis; small GTPase mediated signal transduction