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Semaphorin 3a (SEMA3A) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002113
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MBS2002113 is an antibody targeting SEMA3A. Also known as Polyclonal Antibody to Semaphorin 3A (SEMA3A). Reactive in Rat. Host: Rabbit. More details

$235 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Semaphorin 3A (SEMA3A), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Semaphorin 3A (SEMA3A)
Product Gene Name
anti-SEMA3A antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- RLKLSYKEML ESNNVITFNG LANSSSYHTF LLDEERSRLY VGAKDHIFSF NLVNIKDFQK IVWPVSYTRR DECKWAGKDI LKECANFIKV LKAYNQTHLY ACGTGAFHPI CTYIEVGHHP
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
0.62mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against SEMA3A. It has been selected for its ability to recognize SEMA3A in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: SEMA3A (MBS2002113)
Immunogen: SEMA3A (MBS2011615)
Matching Pairs
Unconjugated Antibody: SEMA3A (MBS2002113)
APC-CY7 Conjugated Antibody: SEMA3A (MBS2083388)
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Molecular Weight
88,808 Da
3D Structure
ModBase 3D Structure for Q63548
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant SEMA3A (Arg31~Pro150) expressed in E.coli.
Cross Reactivity
Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2083390
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-SEMA3A antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-SEMA3A antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-SEMA3A antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-SEMA3A Polyclonal Antibody – Cat# MBS2002113

Immunohistochemistry (IHC) of anti-SEMA3A antibody

DAB staining on IHC-P; Samples: Rat Intestine Tissue)
Rabbit Anti-SEMA3A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002113

Other Notes

Small volumes of anti-SEMA3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SEMA3A. It may not necessarily be applicable to this product.

NCBI GI #
8394255
NCBI GeneID
29751
NCBI Accession #
NP_059006.1
UniProt Primary Accession #
Q63548
UniProt Related Accession #
Q63548
GenBank Nucleotide #
NM_017310.1
NCBI Official Full Name
semaphorin-3A
NCBI Official Synonym Full Names
semaphorin 3A
NCBI Official Symbol
Sema3a
UniProt Protein Name
Semaphorin-3A
UniProt Synonym Protein Names
Semaphorin III; Sema III
Protein Family
Semaphorin
UniProt Gene Name
Sema3a
UniProt Synonym Gene Names
Sema III
NCBI Protein Information
semaphorin-3A

NCBI Summary for SEMA3A

induces neuronal cell death; induces apoptosis of retinal ganglion cells in response to injury [RGD, Feb 2006]

UniProt Comments for SEMA3A

SEMA3A: May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity)

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: axon; dendrite; extracellular space

Molecular Function: chemorepellent activity; semaphorin receptor binding

Biological Process: apoptosis; axon extension involved in axon guidance; axon guidance; axonal fasciculation; branchiomotor neuron axon guidance; dendrite morphogenesis; facial nerve structural organization; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; motor axon guidance; negative chemotaxis; negative regulation of axon extension; negative regulation of axon extension involved in axon guidance; nerve development; neuron migration; olfactory bulb development; regulation of axon extension involved in axon guidance; regulation of heart rate; trigeminal nerve structural organization
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Research Articles on SEMA3A

1. a Sema3A-initiated apoptotic signaling complex regulates the apoptosis of sympathetic neurons during the period of naturally occurring cell death during development of the peripheral nervous system.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SEMA3A antibody

 Reference Product  PubMed Publications
 Nrp1 antibody  >92 publications with SEMA3A and Nrp1
 Crmp1 antibody  >19 publications with SEMA3A and Crmp1
 Plxna3 antibody  >17 publications with SEMA3A and Plxna3
 Dpysl4 antibody  >5 publications with SEMA3A and Dpysl4
 Rnd1 antibody  >3 publications with SEMA3A and Rnd1
 Farp2 antibody  >3 publications with SEMA3A and Farp2
 Dpysl3 antibody  >3 publications with SEMA3A and Dpysl3
 Plxna4a antibody  >2 publications with SEMA3A and Plxna4a
 Dpysl2 antibody  >2 publications with SEMA3A and Dpysl2
 Rras antibody  >1 publications with SEMA3A and Rras

Pathways associated with anti-SEMA3A antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway antibodies  SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway Diagram
 Sema3A PAK Dependent Axon Repulsion Pathway antibodies  Sema3A PAK Dependent Axon Repulsion Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-SEMA3A antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >112 publications with SEMA3A and Nervous System Diseases
 Inflammation Antibodies  >40 publications with SEMA3A and Inflammation
 Carcinoma Antibodies  >28 publications with SEMA3A and Carcinoma
 Kidney Diseases Antibodies  >23 publications with SEMA3A and Kidney Diseases
 Nerve Degeneration Antibodies  >20 publications with SEMA3A and Nerve Degeneration
 Heart Diseases Antibodies  >19 publications with SEMA3A and Heart Diseases
 Neoplasm Metastasis Antibodies  >15 publications with SEMA3A and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >14 publications with SEMA3A and Lung Neoplasms
 Breast Neoplasms Antibodies  >13 publications with SEMA3A and Breast Neoplasms
 Neoplasm Invasiveness Antibodies  >12 publications with SEMA3A and Neoplasm Invasiveness

Organs/Tissues associated with anti-SEMA3A antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >328 publications with SEMA3A and Brain
 Adipose Tissue Antibodies  >2 publications with SEMA3A and Adipose Tissue
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