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Growth Differentiation Factor 2 (GDF2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002142
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MBS2002142 is an antibody targeting GDF2. Also known as Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2). Reactive in Mouse, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Growth Differentiation Factor 2 (GDF2), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Growth Differentiation Factor 2 (GDF2)
Product Gene Name
anti-GDF2 antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- QKPLQNWEQ ASPGENAHSS LGLSGAGEEG VFDLQMFLEN MKVDFLRSLN LSGIPSQDKT RAEPPQYMID LYNRYTTDKS STPASNIVRS FSVEDAISTA ATEDFPFQKH ILIFNISIPR HEQITRAELR LYVSCQNDVD STHGLEGSMV VYDVLEDS
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against GDF2. It has been selected for its ability to recognize GDF2 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: GDF2 (MBS2002142)
Immunogen: GDF2 (MBS2009907)
Matching Pairs
Unconjugated Antibody: GDF2 (MBS2002142)
APC-CY7 Conjugated Antibody: GDF2 (MBS2058344)
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Molecular Weight
47,703 Da
3D Structure
ModBase 3D Structure for Q9WV56
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant GDF2 (Gln22~Ser178) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2058348
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-GDF2 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-GDF2 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-GDF2 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-GDF2 Polyclonal Antibody – Cat# MBS2002142

Immunohistochemistry (IHC) of anti-GDF2 antibody

DAB staining on fromalin fixed paraffin-embedded Liver tissue)
Rabbit Anti-GDF2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002142

Other Notes

Small volumes of anti-GDF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GDF2. It may not necessarily be applicable to this product.

NCBI GI #
83582807
NCBI GeneID
12165
NCBI Accession #
NP_062379.3
UniProt Primary Accession #
Q9WV56
UniProt Secondary Accession #
Q3ZAS6; Q9QZE0
UniProt Related Accession #
Q9WV56
GenBank Nucleotide #
NM_019506.4
NCBI Official Full Name
growth/differentiation factor 2 preproprotein
NCBI Official Synonym Full Names
growth differentiation factor 2
NCBI Official Symbol
Gdf2
NCBI Official Synonym Symbols
Bmp9
UniProt Protein Name
Growth/differentiation factor 2
UniProt Synonym Protein Names
Bone morphogenetic protein 9; BMP-9
Protein Family
Growth/differentiation factor
UniProt Gene Name
Gdf2
UniProt Synonym Gene Names
Bmp9; GDF-2; BMP-9
NCBI Protein Information
growth/differentiation factor 2

NCBI Summary for GDF2

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates cartilage and bone development, angiogenesis and differentiation of cholinergic central nervous system neurons. Homozygous null mice exhibit malformations of the vasculature and skeleton. [provided by RefSeq, Jul 2016]
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UniProt Comments for GDF2

GDF2: Could be involved in bone formation. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14|14 B

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; protein binding; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; angiogenesis; blood vessel morphogenesis; BMP signaling pathway; branching involved in blood vessel morphogenesis; cell development; cellular iron ion homeostasis; glucose metabolic process; negative regulation of cell growth; negative regulation of endothelial cell proliferation; neuron differentiation; osteoblast differentiation; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of endothelial cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of interleukin-8 production; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of apoptosis; regulation of MAPK cascade; regulation of transforming growth factor beta receptor signaling pathway; vasculogenesis
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Research Articles on GDF2

1. results provide a better understanding into how BMP-9 induces osteoblast differentiation and its synergy with IGF-2 at the signaling level.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GDF2 antibody

 Reference Product  PubMed Publications
 Acvrl1 antibody  >29 publications with GDF2 and Acvrl1
 Bmpr2 antibody  >23 publications with GDF2 and Bmpr2
 Hey1 antibody  >6 publications with GDF2 and Hey1
 Smad5 antibody  >5 publications with GDF2 and Smad5
 Acvr1 antibody  >3 publications with GDF2 and Acvr1
 Smad9 antibody  >1 publications with GDF2 and Smad9
 Bmpr1a antibody  >1 publications with GDF2 and Bmpr1a
 Acvr2b antibody  >1 publications with GDF2 and Acvr2b

Diseases associated with anti-GDF2 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Abnormalities Antibodies  >6 publications with GDF2 and Cardiovascular Abnormalities
 Disease Models, Animal Antibodies  >6 publications with GDF2 and Disease Models, Animal
 Breast Neoplasms Antibodies  >5 publications with GDF2 and Breast Neoplasms
 Hypertension Antibodies  >4 publications with GDF2 and Hypertension
 Lung Diseases Antibodies  >4 publications with GDF2 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with GDF2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with GDF2 and Liver Neoplasms
 Inflammation Antibodies  >3 publications with GDF2 and Inflammation
 Neoplasms, Experimental Antibodies  >2 publications with GDF2 and Neoplasms, Experimental
 Fibrosis Antibodies  >2 publications with GDF2 and Fibrosis

Organs/Tissues associated with anti-GDF2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with GDF2 and Liver
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