Beta-Site APP Cleaving Enzyme 2 (bACE2) Antibody – Rabbit Polyclonal

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein undergoes proteolytic processing to generate an active endopeptidase enzyme. This transmembrane protease catalyzes the proteolysis of amyloid precursor protein to produce amyloid beta peptide. Mice lacking the encoded product exhibit increased pancreatic beta cell mass and improved glucose tolerance due to increased insulin secretion. [provided by RefSeq, Jul 2016]

BACE2: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Belongs to the peptidase A1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.45; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 16|16 C4

Cellular Component: endoplasmic reticulum; endosome; Golgi apparatus; integral component of membrane; membrane

Molecular Function: amyloid-beta binding; aspartic-type endopeptidase activity; hydrolase activity; peptidase activity

Biological Process: beta-amyloid metabolic process; membrane protein ectodomain proteolysis; negative regulation of amyloid precursor protein biosynthetic process; protein catabolic process; proteolysis