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Intercellular Adhesion Molecule 1 (ICAM1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002224
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MBS2002224 is an antibody targeting ICAM1. Also known as Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1). Reactive in Mouse. Host: Rabbit. More details

$165 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Intercellular Adhesion Molecule 1 (ICAM1), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Intercellular Adhesion Molecule 1 (ICAM1)
Product Gene Name
anti-ICAM1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific Affinity Chromatography.
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against ICAM1. It has been selected for its ability to recognize ICAM1 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition
Matching Pairs
Unconjugated Antibody: ICAM1 (MBS2002224)
Immunogen: ICAM1 (MBS2012407)
Matching Pairs
Unconjugated Antibody: ICAM1 (MBS2002224)
APC-CY7 Conjugated Antibody: ICAM1 (MBS2043820)
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Molecular Weight
58,753 Da
3D Structure
ModBase 3D Structure for P13597
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant ICAM1 (Ser328~Ser465) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2043824
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-ICAM1 antibody
WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM
Application Notes for anti-ICAM1 antibody
Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-ICAM1 antibody

Western Blot: Sample: Recombinant ICAM1, Mouse.
Rabbit Anti-ICAM1 Polyclonal Antibody – Cat# MBS2002224

Immunohistochemistry (IHC) of anti-ICAM1 antibody

DABstainingonIHC-P.Samples:MouseTissue)
Rabbit Anti-ICAM1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002224

Other Notes

Small volumes of anti-ICAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ICAM1. It may not necessarily be applicable to this product.

NCBI GI #
21389311
NCBI GeneID
15894
NCBI Accession #
NP_034623.1
UniProt Primary Accession #
P13597
UniProt Secondary Accession #
Q61828
UniProt Related Accession #
P13597
GenBank Nucleotide #
NM_010493.3
NCBI Official Full Name
intercellular adhesion molecule 1
NCBI Official Synonym Full Names
intercellular adhesion molecule 1
NCBI Official Symbol
Icam1
NCBI Official Synonym Symbols
CD54; Ly-47; Icam-1; MALA-2
UniProt Protein Name
Intercellular adhesion molecule 1
UniProt Synonym Protein Names
MALA-2; MyD10; CD_antigen: CD54
Protein Family
Intercellular adhesion molecule
UniProt Gene Name
Icam1
UniProt Synonym Gene Names
Icam-1; ICAM-1
NCBI Protein Information
intercellular adhesion molecule 1

NCBI Summary for ICAM1

This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1. It participates in the innate immune response. [provided by RefSeq, Aug 2016]

UniProt Comments for ICAM1

ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9 A3|9 7.69 cM

Cellular Component: cell surface; external side of plasma membrane; extracellular exosome; extracellular matrix; extracellular space; focal adhesion; immunological synapse; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; plasma membrane

Molecular Function: integrin binding; protein complex binding

Biological Process: acute inflammatory response to antigenic stimulus; adhesion of symbiont to host; cell adhesion; cell adhesion mediated by integrin; cellular response to glucose stimulus; establishment of endothelial intestinal barrier; leukocyte adhesion; negative regulation of calcium ion transport; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of actin filament polymerization; positive regulation of cellular extravasation; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of vasoconstriction; receptor-mediated virion attachment to host cell; regulation of cell adhesion; regulation of cell shape; regulation of ruffle assembly; sensory perception of sound; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; T cell antigen processing and presentation
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Research Articles on ICAM1

1. Data show that intercellular adhesion molecule 1 (ICAM-1) and ICAM-2 on B cells are essential for long-lasting cognate T follicular helper (Tfh)-B cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expansion

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ICAM1 antibody

 Reference Product  PubMed Publications
 Tnf antibody  >3666 publications with ICAM1 and Tnf
 Vcam1 antibody  >140 publications with ICAM1 and Vcam1
 Ncam1 antibody  >130 publications with ICAM1 and Ncam1
 Stat1 antibody  >116 publications with ICAM1 and Stat1
 Itgam antibody  >25 publications with ICAM1 and Itgam
 Nfkb1 antibody  >23 publications with ICAM1 and Nfkb1
 Irf1 antibody  >18 publications with ICAM1 and Irf1
 Itgal antibody  >7 publications with ICAM1 and Itgal
 Itgb2 antibody  >7 publications with ICAM1 and Itgb2
 Ezr antibody  >1 publications with ICAM1 and Ezr

Pathways associated with anti-ICAM1 antibody

 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram

Diseases associated with anti-ICAM1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6087 publications with ICAM1 and Inflammation
 Necrosis Antibodies  >5057 publications with ICAM1 and Necrosis
 Cardiovascular Diseases Antibodies  >3917 publications with ICAM1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1584 publications with ICAM1 and Atherosclerosis
 Heart Diseases Antibodies  >1085 publications with ICAM1 and Heart Diseases
 Reperfusion Injury Antibodies  >934 publications with ICAM1 and Reperfusion Injury
 Myocardial Ischemia Antibodies  >839 publications with ICAM1 and Myocardial Ischemia
 Kidney Diseases Antibodies  >821 publications with ICAM1 and Kidney Diseases
 Hypertension Antibodies  >573 publications with ICAM1 and Hypertension
 Asthma Antibodies  >514 publications with ICAM1 and Asthma

Organs/Tissues associated with anti-ICAM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1887 publications with ICAM1 and Lung
 Brain Antibodies  >1262 publications with ICAM1 and Brain
 Kidney Antibodies  >1248 publications with ICAM1 and Kidney
 Liver Antibodies  >1232 publications with ICAM1 and Liver
 Skin Antibodies  >1228 publications with ICAM1 and Skin
 Embryonic Tissue Antibodies  >793 publications with ICAM1 and Embryonic Tissue
 Bone Antibodies  >704 publications with ICAM1 and Bone
 Intestine Antibodies  >567 publications with ICAM1 and Intestine
 Bone Marrow Antibodies  >495 publications with ICAM1 and Bone Marrow
 Lymph Node Antibodies  >424 publications with ICAM1 and Lymph Node
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