Bcl2 Like Protein 11 () Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]

BIM: a pro-apoptotic member of the BCL-2 protein family. Interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. Nineteen alternatively spliced transcript variants of this gene have been reported.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: cytoplasmic dynein complex; cytosol; endomembrane system; extrinsic component of membrane; mitochondrial outer membrane; mitochondrion

Molecular Function: microtubule binding; protein binding; protein heterodimerization activity; protein kinase binding

Biological Process: apoptosis; apoptotic process involved in embryonic digit morphogenesis; B cell apoptosis; B cell homeostasis; brain development; cell-matrix adhesion; cellular process regulating host cell cycle in response to virus; cellular response to glucocorticoid stimulus; DNA damage response, signal transduction resulting in induction of apoptosis; ear development; in utero embryonic development; kidney development; lumen formation; male gonad development; mammary gland development; meiosis I; myeloid cell homeostasis; odontogenesis of dentine-containing teeth; pigmentation during development; positive regulation of apoptosis; positive regulation of apoptosis by virus; positive regulation of cell cycle; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of fibroblast apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of IRE1-mediated unfolded protein response; positive regulation of neuron apoptotic process; positive regulation of protein homooligomerization; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of release of cytochrome c from mitochondria; post-embryonic organ morphogenesis; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of apoptosis; regulation of developmental pigmentation; regulation of organ growth; spermatogenesis; spleen development; T cell homeostasis; thymus development