Peroxiredoxin 5 (PRDX5) Antibody – Rabbit Polyclonal

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017]

PRDX5: Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling. Belongs to the peroxiredoxin 2 family. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: EC 1.11.1.15; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; extracellular exosome; extracellular space; intracellular membrane-bound organelle; mitochondrial matrix; mitochondrion; nucleus; perinuclear region of cytoplasm; peroxisomal matrix; peroxisome

Molecular Function: caspase inhibitor activity; peroxidase activity; protein dimerization activity; receptor binding; thioredoxin peroxidase activity

Biological Process: apoptosis; cell redox homeostasis; cellular oxidant detoxification; cellular response to oxidative stress; cellular response to reactive oxygen species; inflammatory response; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of transcription from RNA polymerase III promoter; response to oxidative stress