Nucleolin (NCL) Antibody – Rabbit Polyclonal

NCL: the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and preribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-RNA transcription and ribosome assembly.

Protein type: DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding

Chromosomal Location of Human Ortholog: 1 C5|1 43.94 cM

Cellular Component: cell cortex; cell surface; cytoplasm; cytoplasmic ribonucleoprotein granule; dense fibrillar component; extracellular exosome; fibrillar center; intracellular ribonucleoprotein complex; membrane; nucleolus; nucleoplasm; nucleus

Molecular Function: calcium ion binding; DNA binding; DNA topoisomerase binding; ErbB-4 class receptor binding; histone binding; identical protein binding; laminin binding; mRNA 5'-UTR binding; nucleic acid binding; protein binding; protein C-terminus binding; receptor binding; RNA binding; rRNA primary transcript binding; sequence-specific DNA binding; single-stranded DNA binding; telomeric DNA binding

Biological Process: angiogenesis; cellular response to epidermal growth factor stimulus; endocytosis; negative regulation of apoptosis; negative regulation of translation; positive regulation of interleukin-6 secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of rRNA processing