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Neutrophil Activating Protein 3 (NAP3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002288
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MBS2002288 is an antibody targeting NAP3. Also known as Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3). Reactive in Mouse, Rat. Host: Rabbit. More details

$200 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neutrophil Activating Protein 3 (NAP3), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Neutrophil Activating Protein 3 (NAP3)
Product Gene Name
anti-NAP3 antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-API ANE LRCQCLQTMA GIHLKNIQSL KVLPSGPHCT QTEVIATLKN GREACLDPEA PLVQKIVQKM LKGVPK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against NAP3. It has been selected for its ability to recognize NAP3 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: NAP3 (MBS2002288)
Biotin Conjugated Antibody: NAP3 (MBS2006601)
Matching Pairs
Unconjugated Antibody: NAP3 (MBS2002288)
Immunogen: NAP3 (MBS2012245)
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Molecular Weight
10,254 Da
3D Structure
ModBase 3D Structure for P12850
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant NAP3 (Ala25~Lys96) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2035778
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-NAP3 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-NAP3 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-NAP3 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-NAP3 Polyclonal Antibody – Cat# MBS2002288

Immunohistochemistry (IHC) of anti-NAP3 antibody

DABstainingonIHC-P.Samples:MouseTissue)
Rabbit Anti-NAP3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002288

Other Notes

Small volumes of anti-NAP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NAP3. It may not necessarily be applicable to this product.

NCBI GI #
6680109
NCBI GeneID
14825
NCBI Accession #
NP_032202.1
UniProt Primary Accession #
P12850
UniProt Related Accession #
P12850
GenBank Nucleotide #
NM_008176.3
NCBI Official Full Name
growth-regulated alpha protein
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 1
NCBI Official Symbol
Cxcl1
NCBI Official Synonym Symbols
KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1
UniProt Protein Name
Growth-regulated alpha protein
UniProt Synonym Protein Names
C-X-C motif chemokine 1; Platelet-derived growth factor-inducible protein KC; Secretory protein N51
UniProt Gene Name
Cxcl1
UniProt Synonym Gene Names
Gro; Gro1; Mgsa; Scyb1; HSF
NCBI Protein Information
growth-regulated alpha protein

NCBI Summary for NAP3

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
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UniProt Comments for NAP3

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5 E1|5 44.78 cM

Cellular Component: extracellular region; extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding; cytokine activity; growth factor activity

Biological Process: acute inflammatory response; chemotaxis; defense response; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; immune response; inflammatory response; neutrophil chemotaxis; positive regulation of potassium ion transport; positive regulation of superoxide anion generation; response to lipopolysaccharide; response to molecule of bacterial origin
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Research Articles on NAP3

1. this study demonstrates that in vivo blocking of CXCL1 and CXCL2 can significantly reduce the Mycobacterium tuberculosis-induced bioactive IL-1beta production

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NAP3 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram

Diseases associated with anti-NAP3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1183 publications with NAP3 and Inflammation
 Necrosis Antibodies  >568 publications with NAP3 and Necrosis
 Disease Models, Animal Antibodies  >434 publications with NAP3 and Disease Models, Animal
 Lung Diseases Antibodies  >337 publications with NAP3 and Lung Diseases
 Cardiovascular Diseases Antibodies  >198 publications with NAP3 and Cardiovascular Diseases
 Lung Injury Antibodies  >174 publications with NAP3 and Lung Injury
 Pneumonia Antibodies  >116 publications with NAP3 and Pneumonia
 Wounds and Injuries Antibodies  >98 publications with NAP3 and Wounds and Injuries
 Reperfusion Injury Antibodies  >97 publications with NAP3 and Reperfusion Injury
 Fibrosis Antibodies  >91 publications with NAP3 and Fibrosis

Organs/Tissues associated with anti-NAP3 antibody

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >65 publications with NAP3 and Connective Tissue
 Embryonic Tissue Antibodies  >46 publications with NAP3 and Embryonic Tissue
 Spinal Cord Antibodies  >33 publications with NAP3 and Spinal Cord
 Adipose Tissue Antibodies  >24 publications with NAP3 and Adipose Tissue
 Ovary Antibodies  >17 publications with NAP3 and Ovary
 Mammary Gland Antibodies  >10 publications with NAP3 and Mammary Gland
 Extraembryonic Tissue Antibodies  >1 publications with NAP3 and Extraembryonic Tissue
 Testis Antibodies  >1 publications with NAP3 and Testis
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