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Transglutaminase 1, Keratinocyte (TGM1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002333
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MBS2002333 is an antibody targeting TGM1. Also known as Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1). Reactive in Mouse, Human, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transglutaminase 1, Keratinocyte (TGM1), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Transglutaminase 1, Keratinocyte (TGM1)
Product Gene Name
anti-TGM1 antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -LIGN WTGDYSRGTN PSAWVGSVEI LLSYLRTGYS VPYGQCWVFA GVTTTVLRCL GFATRTVTNF NSAHDTDTSL TMDIYFDENM KPLEHLNHDS VWNFHVWNDC WMKRPDLPSG FDGWQVVDAT PQETSSGIFC CGPCSVESVK NGLVYMKYDT PFIFAEVNSD KVYWQRQDDG SFKIVYVEEK AIGTLIVTKA IHSNNREDIT HIYKHPEGSE AERRAVEKAA AHGSKPNVYA TRDSAEDVAM QVEAQDAVMG QDLAVSVVLT NRGSSRR
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human, Rat
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.73mg/ml (lot specific)
Preparation and Storage
Avoid repeated freeze / thaw cycles.
Store at 4°C for frequent use.
Aliquot and store at -20°C for 24 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: TGM1 (MBS2002333)
Biotin Conjugated Antibody: TGM1 (MBS2006300)
Matching Pairs
Unconjugated Antibody: TGM1 (MBS2002333)
Immunogen: TGM1 (MBS2010826)
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3D Structure
ModBase 3D Structure for Q9JLF6
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Organism Species
Mus musculus (Mouse)
Source
Polyclonal antibody preparation
Cross Reactivity
Mouse
Traits
Liquid
Immunogen
Recombinant TGM1 (Leu337~Arg607 (Accession # Q9JLF6)) expressed in E.coli ( MBS2010826 ).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-TGM1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, Immunoprecipitation (IP).
Application Notes for anti-TGM1 antibody
Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-TGM1 antibody

Western Blot:
Sample: Lane1: Mouse Kidney Tissue;
Lane2: Mouse Spleen Tissue;
Lane3: Mouse Placenta Tissue.
Rabbit Anti-TGM1 Polyclonal Antibody – Cat# MBS2002333

Western Blot (WB) of anti-TGM1 antibody

Western Blot:
Sample: Recombinant TGM1, Mouse.
Rabbit Anti-TGM1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002333

Other Notes

Small volumes of anti-TGM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TGM1. It may not necessarily be applicable to this product.

NCBI GI #
239787890
NCBI GeneID
21816
NCBI Accession #
NP_001155186.1
UniProt Primary Accession #
Q9JLF6
UniProt Secondary Accession #
Q8R0T9
UniProt Related Accession #
Q9JLF6
GenBank Nucleotide #
NM_001161714.1
NCBI Official Full Name
protein-glutamine gamma-glutamyltransferase K
NCBI Official Synonym Full Names
transglutaminase 1, K polypeptide
NCBI Official Symbol
Tgm1
NCBI Official Synonym Symbols
Tgase1; 2310004J08Rik
UniProt Protein Name
Protein-glutamine gamma-glutamyltransferase K
UniProt Synonym Protein Names
Epidermal TGase; Transglutaminase K; TG(K); TGK; TGase K; Transglutaminase-1; TGase-1
Protein Family
Protein-glutamine gamma-glutamyltransferase
UniProt Gene Name
Tgm1
UniProt Synonym Gene Names
TG(K); TGK; TGase K; TGase-1
NCBI Protein Information
protein-glutamine gamma-glutamyltransferase K

UniProt Comments for TGM1

TGM1: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.

Protein type: EC 2.3.2.13; Transferase

Chromosomal Location of Human Ortholog: 14|14 C3

Cellular Component: cell-cell adherens junction; extracellular exosome; intrinsic component of membrane; membrane

Molecular Function: metal ion binding; protein-glutamine gamma-glutamyltransferase activity; transferase activity; transferase activity, transferring acyl groups

Biological Process: keratinization; keratinocyte differentiation; organ morphogenesis; peptide cross-linking; positive regulation of cell cycle; positive regulation of keratinocyte proliferation; protein metabolic process
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Research Articles on TGM1

1. that the up-regulation of molecular signatures for antimicrobial and innate defense responses is characteristic of skin with a transglutaminase 1 deficiency.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TGM1 antibody

 Reference Product  PubMed Publications
 Aloxe3 antibody  >14 publications with TGM1 and Aloxe3
 Alox12b antibody  >13 publications with TGM1 and Alox12b
 Abca12 antibody  >9 publications with TGM1 and Abca12
 Flg antibody  >5 publications with TGM1 and Flg
 Sprr1a antibody  >1 publications with TGM1 and Sprr1a

Pathways associated with anti-TGM1 antibody

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Formation Of The Cornified Envelope Pathway antibodies  Formation Of The Cornified Envelope Pathway Diagram
 Keratinization Pathway antibodies  Keratinization Pathway Diagram

Diseases associated with anti-TGM1 antibody

 Disease Name  Pubmed Publications
 Ichthyosis, Lamellar Antibodies  >70 publications with TGM1 and Ichthyosis, Lamellar
 Inflammation Antibodies  >7 publications with TGM1 and Inflammation
 Lung Diseases Antibodies  >2 publications with TGM1 and Lung Diseases
 Necrosis Antibodies  >2 publications with TGM1 and Necrosis
 Dry Eye Syndromes Antibodies  >2 publications with TGM1 and Dry Eye Syndromes
 Cardiovascular Diseases Antibodies  >1 publications with TGM1 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >1 publications with TGM1 and Kidney Diseases
 Fibrosis Antibodies  >1 publications with TGM1 and Fibrosis
 Vitamin A Deficiency Antibodies  >1 publications with TGM1 and Vitamin A Deficiency
 Heart Diseases Antibodies  >1 publications with TGM1 and Heart Diseases

Organs/Tissues associated with anti-TGM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >71 publications with TGM1 and Skin
 Eye Antibodies  >6 publications with TGM1 and Eye
 Kidney Antibodies  >2 publications with TGM1 and Kidney
 Lung Antibodies  >2 publications with TGM1 and Lung
 Embryonic Tissue Antibodies  >2 publications with TGM1 and Embryonic Tissue
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