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Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002335
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MBS2002335 is an antibody targeting SIGLEC7. Also known as Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7). Reactive in Human. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7)
Product Gene Name
anti-SIGLEC7 antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS EF-EGM CVHVRCSFSY PVDSQTDSDP VHGYWFRAGN DISWKAPVAT NNPAWAVQEE TRDRFHLLGD PQTKNCTLSI RDARMSDAGR Y
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against SIGLEC7. It has been selected for its ability to recognize SIGLEC7 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: SIGLEC7 (MBS2002335)
Immunogen: SIGLEC7 (MBS2009971)
Matching Pairs
Unconjugated Antibody: SIGLEC7 (MBS2002335)
APC-CY7 Conjugated Antibody: SIGLEC7 (MBS2059080)
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Molecular Weight
16,740 Da
OMIM
AF170485 mRNA
3D Structure
ModBase 3D Structure for Q9Y286
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant SIGLEC7 (Glu38~Tyr121) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2059088
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-SIGLEC7 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-SIGLEC7 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-SIGLEC7 antibody

Western Blot: Sample: Recombinant SIGLEC7, Human.
Rabbit Anti-SIGLEC7 Polyclonal Antibody – Cat# MBS2002335

Immunohistochemistry (IHC) of anti-SIGLEC7 antibody

DAB staining on fromalin fixed paraffin-embedded Liver tissue)
Rabbit Anti-SIGLEC7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002335

Other Notes

Small volumes of anti-SIGLEC7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SIGLEC7. It may not necessarily be applicable to this product.

NCBI GI #
469469047
NCBI GeneID
27036
NCBI Accession #
NP_001264130.1
UniProt Primary Accession #
Q9Y286
UniProt Secondary Accession #
Q9NZQ1; Q9UJ86; Q9UJ87; Q9Y502
UniProt Related Accession #
Q9Y286
GenBank Nucleotide #
NM_001277201.1
NCBI Official Full Name
sialic acid-binding Ig-like lectin 7 isoform 3
NCBI Official Synonym Full Names
sialic acid binding Ig like lectin 7
NCBI Official Symbol
SIGLEC7
NCBI Official Synonym Symbols
p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1
UniProt Protein Name
Sialic acid-binding Ig-like lectin 7
UniProt Synonym Protein Names
Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD_antigen: CD328
Protein Family
Sialic acid-binding Ig-like lectin
UniProt Gene Name
SIGLEC7
UniProt Synonym Gene Names
AIRM1; Siglec-7; AIRM-1
NCBI Protein Information
sialic acid-binding Ig-like lectin 7

UniProt Comments for SIGLEC7

SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: integral component of plasma membrane; plasma membrane

Molecular Function: carbohydrate binding; receptor activity

Biological Process: cell adhesion; regulation of immune response
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Research Articles on SIGLEC7

1. Siglec-7 defines a highly functional natural killer cell subset and inhibits cell-mediated activities.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SIGLEC7 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-SIGLEC7 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >6 publications with SIGLEC7 and Immune System Diseases
 Inflammation Antibodies  >4 publications with SIGLEC7 and Inflammation
 Kidney Diseases Antibodies  >4 publications with SIGLEC7 and Kidney Diseases
 Necrosis Antibodies  >2 publications with SIGLEC7 and Necrosis
 Colorectal Neoplasms Antibodies  >2 publications with SIGLEC7 and Colorectal Neoplasms
 Lung Neoplasms Antibodies  >2 publications with SIGLEC7 and Lung Neoplasms
 Nervous System Diseases Antibodies  >2 publications with SIGLEC7 and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >1 publications with SIGLEC7 and Peripheral Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with SIGLEC7 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-SIGLEC7 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with SIGLEC7 and Blood
 Liver Antibodies  >2 publications with SIGLEC7 and Liver
 Spleen Antibodies  >2 publications with SIGLEC7 and Spleen
 Eye Antibodies  >1 publications with SIGLEC7 and Eye
 Adrenal Gland Antibodies  >1 publications with SIGLEC7 and Adrenal Gland
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