Mitogen Activated Protein Kinase 9 (MAPK9) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

JNK2: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses including UV radiation. Phosphorylates specific transcription factors such as c-Jun and ATF2, mediating immediate-early gene expression. Closely related to JNK1. Both are involved in UV radiation induced apoptosis. Blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells in the mouse. Four alternatively-spliced isoforms have been described.

Protein type: CMGC group; EC 2.7.11.24; JNK subfamily; Kinase, protein; MAPK family; MAPK/JNK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: cytoplasm; cytosol; mitochondrion; neuron projection; nucleoplasm; nucleus

Molecular Function: ATP binding; JUN kinase activity; protein binding; transcription factor binding

Biological Process: cellular response to cadmium ion; cellular response to organic substance; cellular response to reactive oxygen species; Fc-epsilon receptor signaling pathway; JNK cascade; JUN phosphorylation; neuron development; peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of apoptotic signaling pathway; positive regulation of gene expression; positive regulation of macrophage derived foam cell differentiation; positive regulation of podosome assembly; protein amino acid phosphorylation; protein localization to tricellular tight junction; regulation of circadian rhythm; regulation of transcription factor activity; response to mechanical stimulus; response to stress; rhythmic process