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Platelet/Endothelial Cell Adhesion Molecule (PECAM1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002368
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MBS2002368 is an antibody targeting PECAM1. Also known as Biotin-Linked Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1). Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Platelet/Endothelial Cell Adhesion Molecule (PECAM1), Polyclonal Antibody
Full Product Name
Biotin-Linked Antibody to Platelet/Endothelial Cell Adhesion Molecule (PECAM1)
Product Gene Name
anti-PECAM1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against PECAM1 conjugated to biotin. It has been selected for its ability to recognize PECAM1 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Biotin Conjugated Antibody: PECAM1 (MBS2002368)
Immunogen: PECAM1 (MBS2012180)
Matching Pairs
Unconjugated Antibody: PECAM1 (MBS2004527)
Biotin Conjugated Antibody: PECAM1 (MBS2002368)
Molecular Weight
82,536 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (62396775..62404856, complement). Location: 17q23.3
OMIM
173445
3D Structure
ModBase 3D Structure for P16284
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Product Categories/Family for anti-PECAM1 antibody

Biotin Antibody
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-PECAM1 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-PECAM1 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-PECAM1 antibody

(Figure. Western Blot; Sample: Recombinant protein.)
Rabbit Anti-PECAM1 Polyclonal Antibody – Cat# MBS2002368

Other Notes

Small volumes of anti-PECAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PECAM1. It may not necessarily be applicable to this product.

NCBI GI #
313760624
NCBI GeneID
5175
NCBI Accession #
NP_000433.4
UniProt Primary Accession #
P16284
UniProt Secondary Accession #
Q6LDA9; Q8TBH1; Q96RF5; Q96RF6; Q9NP65; Q9NPB7; Q9NPG9; Q9NQS9; Q9NQT0; A8K3S7; D3DU31
UniProt Related Accession #
P16284
GenBank Nucleotide #
NM_000442.4
NCBI Official Full Name
platelet endothelial cell adhesion molecule
NCBI Official Synonym Full Names
platelet/endothelial cell adhesion molecule 1
NCBI Official Symbol
PECAM1
NCBI Official Synonym Symbols
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
UniProt Protein Name
Platelet endothelial cell adhesion molecule
UniProt Synonym Protein Names
EndoCAM; GPIIA'; PECA1
Protein Family
Platelet endothelial cell adhesion molecule
UniProt Gene Name
PECAM1
UniProt Synonym Gene Names
PECAM-1
UniProt Entry Name
PECA1_HUMAN
NCBI Protein Information
platelet endothelial cell adhesion molecule; CD31 antigen

NCBI Summary for PECAM1

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
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UniProt Comments for PECAM1

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; platelet alpha granule membrane; integral to membrane; plasma membrane; cell junction

Molecular Function: protein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; blood coagulation; cell adhesion; signal transduction; leukocyte migration; phagocytosis
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Research Articles on PECAM1

1. PECAM-1 may play a role in regulation of apoptosis as well as adhesion of BCR/ABL-expressing cells to modulate their imatinib sensitivity and would be a possible candidate for therapeutic target in Ph+ leukemias.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PECAM1 antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram

Diseases associated with anti-PECAM1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1637 publications with PECAM1 and Neoplasms
 Inflammation Antibodies  >459 publications with PECAM1 and Inflammation
 Necrosis Antibodies  >387 publications with PECAM1 and Necrosis
 Neoplasms, Experimental Antibodies  >243 publications with PECAM1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >225 publications with PECAM1 and Lung Diseases
 Heart Diseases Antibodies  >216 publications with PECAM1 and Heart Diseases
 Breast Neoplasms Antibodies  >194 publications with PECAM1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >177 publications with PECAM1 and Lung Neoplasms
 Liver Diseases Antibodies  >161 publications with PECAM1 and Liver Diseases
 Atherosclerosis Antibodies  >138 publications with PECAM1 and Atherosclerosis

Organs/Tissues associated with anti-PECAM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >3196 publications with PECAM1 and Vascular
 Blood Antibodies  >2838 publications with PECAM1 and Blood
 Muscle Antibodies  >634 publications with PECAM1 and Muscle
 Bone Marrow Antibodies  >416 publications with PECAM1 and Bone Marrow
 Lung Antibodies  >400 publications with PECAM1 and Lung
 Heart Antibodies  >323 publications with PECAM1 and Heart
 Brain Antibodies  >308 publications with PECAM1 and Brain
 Liver Antibodies  >283 publications with PECAM1 and Liver
 Umbilical Cord Antibodies  >221 publications with PECAM1 and Umbilical Cord
 Kidney Antibodies  >220 publications with PECAM1 and Kidney
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