Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) Antibody – Rabbit Polyclonal

CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3 H2|3 70.18 cM

Cellular Component: extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: extracellular matrix binding; growth factor binding; heparin binding; insulin-like growth factor binding; integrin binding

Biological Process: cell adhesion; cell-cell signaling; chemotaxis; extracellular matrix organization; intussusceptive angiogenesis; negative regulation of apoptosis; osteoblast differentiation; positive regulation of apoptosis; positive regulation of BMP signaling pathway; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of protein kinase activity; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; signal transduction