Glucokinase Regulatory Protein (GKRP) Antibody – Rabbit Polyclonal

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008]

GCKR: a key regulator of glucokinase in the liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. When expressed alone, both glucokinase and GCKR localize predominantly to the cytoplasm. Co-expression induces both proteins to localize in the nucleus.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol

Molecular Function: enzyme inhibitor activity; protein domain specific binding; protein binding; enzyme binding; carbohydrate binding

Biological Process: negative regulation of glucokinase activity; urate metabolic process; protein import into nucleus, translocation; hexose transport; carbohydrate metabolic process; cell glucose homeostasis; pathogenesis; glucose transport; transmembrane transport; response to fructose stimulus; positive regulation of glucokinase activity

Disease: Fasting Plasma Glucose Level Quantitative Trait Locus 5