Colony Stimulating Factor Receptor, Macrophage (MCFSR) Antibody – Rabbit Polyclonal

CSFR: an oncogenic tyrosine kinase receptor for CSF-1 (M-CSF). Drives growth and development of monocytes. Binding of CSF-1 induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins. There are at least five major tyrosine autophosphorylation sites. Two point mutations seen in 10-20% of patients with acute myeloid leukemia, chronic myelomonocytic leukemia or myelodysplasia. One mutation appears to be both somatic and germline, and disrupts Cbl binding and receptor turnover. v-fms lacks the Cbl binding site and causes feline leukemia. Mutations may also develop after chemotherapy for lymphoma. A distinct point mutation was found in some cases of hepatocellular carcinoma and related to increased expression, and another mutation was found in 2 of 40 patients with idiopathic myelofibrosis. Expression is elevated in breast tumors and cell lines, and expression in xenografts and transgenic mice has been correlated with xenograft growth and breast cancer development. Inhibitors: Ki-20227 and other Kit/PDGFR inhibitors.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 18 E1|18 34.41 cM

Cellular Component: cell surface; CSF1-CSF1R complex; integral component of membrane; intracellular membrane-bound organelle; membrane; nucleoplasm; plasma membrane

Molecular Function: ATP binding; cytokine binding; kinase activity; macrophage colony-stimulating factor receptor activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: axon guidance; cell proliferation; cellular response to cytokine stimulus; cytokine-mediated signaling pathway; forebrain neuron differentiation; hemopoiesis; immune system process; inflammatory response; innate immune response; intercellular junction maintenance; macrophage colony-stimulating factor signaling pathway; negative regulation of apoptosis; negative regulation of cell proliferation; olfactory bulb development; osteoclast differentiation; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphoinositide-mediated signaling; phosphorylation; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of chemokine secretion; positive regulation of ERK1 and ERK2 cascade; positive regulation of osteoclast differentiation; positive regulation of protein phosphorylation; positive regulation of protein serine/threonine kinase activity; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid phosphorylation; protein autophosphorylation; regulation of actin cytoskeleton reorganization; regulation of bone resorption; regulation of cell shape; ruffle organization; transmembrane receptor protein tyrosine kinase signaling pathway