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Beta-2-Microglobulin (b2M) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002465
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MBS2002465 is an antibody targeting b2M. Also known as Polyclonal Antibody to Beta-2-Microglobulin (b2M). Reactive in Mouse, Human, Rat. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Beta-2-Microglobulin (b2M), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Beta-2-Microglobulin (b2M)
Product Gene Name
anti-b2M antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG S-QKTPQIQV Y SRHPPENGKP NILNCYVTQF HPPHIEIQML KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC RVKHDSMAEP KTVYWDRDM
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Human, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against b2M. It has been selected for its ability to recognize b2M in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: b2M (MBS2002465)
Biotin Conjugated Antibody: b2M (MBS2006843)
Matching Pairs
Unconjugated Antibody: b2M (MBS2002465)
Immunogen: b2M (MBS2010093)
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Molecular Weight
13,779 Da
3D Structure
ModBase 3D Structure for P01887
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant b2M (Gln22~Met119) expressed in E.coli.
Cross Reactivity
Human, Mouse, Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2040198
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-b2M antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-b2M antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-b2M antibody

Western Blot: Sample: Lane1: Mouse Serum; Lane2: Mouse Spleen Tissue; Lane3: Mouse Liver Tissue; Lane4: Rat Liver Tissue; Lane5: Human Urine.
Rabbit Anti-b2M Polyclonal Antibody – Cat# MBS2002465

Western Blot (WB) of anti-b2M antibody

Western Blot: Sample: Recombinant b2M, Mouse.
Rabbit Anti-b2M Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002465

Immunohistochemistry (IHC) of anti-b2M antibody

DAB staining on IHC-P; Samples: Mouse Stomach Tissue.
Rabbit Anti-b2M Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002465

Other Notes

Small volumes of anti-b2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for b2M. It may not necessarily be applicable to this product.

NCBI GI #
31981890
NCBI GeneID
12010
NCBI Accession #
NP_033865.2
UniProt Primary Accession #
P01887
UniProt Secondary Accession #
Q91XJ8
UniProt Related Accession #
P01887
GenBank Nucleotide #
NM_009735.3
NCBI Official Full Name
beta-2-microglobulin
NCBI Official Synonym Full Names
beta-2 microglobulin
NCBI Official Symbol
B2m
NCBI Official Synonym Symbols
Ly-m11; beta2m; beta2-m
UniProt Protein Name
Beta-2-microglobulin
Protein Family
Beta-2-microglobulin
UniProt Gene Name
B2m
NCBI Protein Information
beta-2-microglobulin

UniProt Comments for b2M

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2 E5|2 60.55 cM

Cellular Component: cytosol; external side of plasma membrane; extracellular region; extracellular space; focal adhesion; Golgi apparatus; membrane; MHC class I protein complex; plasma membrane

Molecular Function: identical protein binding; protein binding

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; cellular defense response; ferric iron import; immune response; immune system process; iron ion homeostasis; iron ion transport; positive regulation of protein binding; positive regulation of receptor-mediated endocytosis; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; protein refolding; regulation of erythrocyte differentiation; response to molecule of bacterial origin; T cell differentiation in thymus
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Research Articles on b2M

1. The results show that, although other factors influence the fibril growth kinetics, a striking difference in the solubility of the proteins is a key determinant of the different amyloidogenicity of human B2M and mouse B2M.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-b2M antibody

 Reference Product  PubMed Publications
 Tap1 antibody  >7 publications with b2M and Tap1

Pathways associated with anti-b2M antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 ER-Phagosome Pathway antibodies  ER-Phagosome Pathway Diagram
 Endosomal/Vacuolar Pathway antibodies  Endosomal/Vacuolar Pathway Diagram

Diseases associated with anti-b2M antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >92 publications with b2M and Cardiovascular Diseases
 Kidney Diseases Antibodies  >80 publications with b2M and Kidney Diseases
 Inflammation Antibodies  >50 publications with b2M and Inflammation
 Carcinoma Antibodies  >47 publications with b2M and Carcinoma
 Renal Insufficiency Antibodies  >36 publications with b2M and Renal Insufficiency
 Disease Models, Animal Antibodies  >31 publications with b2M and Disease Models, Animal
 Necrosis Antibodies  >25 publications with b2M and Necrosis
 Proteinuria Antibodies  >25 publications with b2M and Proteinuria
 Adenocarcinoma Antibodies  >23 publications with b2M and Adenocarcinoma
 Liver Diseases Antibodies  >22 publications with b2M and Liver Diseases

Organs/Tissues associated with anti-b2M antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >325 publications with b2M and Blood
 Kidney Antibodies  >130 publications with b2M and Kidney
 Bone Antibodies  >93 publications with b2M and Bone
 Bone Marrow Antibodies  >71 publications with b2M and Bone Marrow
 Liver Antibodies  >48 publications with b2M and Liver
 Brain Antibodies  >40 publications with b2M and Brain
 Muscle Antibodies  >39 publications with b2M and Muscle
 Heart Antibodies  >33 publications with b2M and Heart
 Skin Antibodies  >33 publications with b2M and Skin
 Lung Antibodies  >24 publications with b2M and Lung
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