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Endothelin Converting Enzyme 1 (ECE1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002484
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MBS2002484 is an antibody targeting ECE1. Also known as Polyclonal Antibody to Endothelin Converting Enzyme 1 (ECE1). Reactive in Mouse. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Endothelin Converting Enzyme 1 (ECE1), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Endothelin Converting Enzyme 1 (ECE1)
Product Gene Name
anti-ECE1 antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-APA IN WLPFLNTIFY PVEINESEPI VVYDKEYLRQ VSTLINNTDK CLLNNYMMWN LVRKTSSFLD QRFQDADEKF MEVMYGTKKT CIPRWKFCVS DTENNLGFAL GPMFVKATFA EDSKNIASEI IMEIKKAFEE SLSTLKWMDE ETRRSAKEKA DAIYNMIGYP NFIMDPKELD KVFNDYTAVP DLYFENAMRF FNFSWRVTAD QLRKAPNRDQ WSMTPPMVNA YYSPTKNEIV FPAGILQAPF YTRSSPN
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against ECE1. It has been selected for its ability to recognize ECE1 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: ECE1 (MBS2002484)
Immunogen: ECE1 (MBS2009887)
Matching Pairs
Unconjugated Antibody: ECE1 (MBS2002484)
APC-CY7 Conjugated Antibody: ECE1 (MBS2042955)
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Molecular Weight
87,085 Da
3D Structure
ModBase 3D Structure for Q4PZA2
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant ECE1 (Ala326~Asn577) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2042957
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-ECE1 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-ECE1 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-ECE1 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-ECE1 Polyclonal Antibody – Cat# MBS2002484

Immunohistochemistry (IHC) of anti-ECE1 antibody

DABstainingonIHC-P.Samples:MouseTissue)
Rabbit Anti-ECE1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002484

Other Notes

Small volumes of anti-ECE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ECE1. It may not necessarily be applicable to this product.

NCBI GI #
40556286
NCBI GeneID
230857
NCBI Accession #
NP_955011.1
UniProt Primary Accession #
Q4PZA2
UniProt Secondary Accession #
Q4PZ99; Q4PZA1; Q6P9Q9; B1AXF9
UniProt Related Accession #
Q4PZA2
GenBank Nucleotide #
NM_199307.2
NCBI Official Full Name
endothelin-converting enzyme 1
NCBI Official Synonym Full Names
endothelin converting enzyme 1
NCBI Official Symbol
Ece1
NCBI Official Synonym Symbols
ECE-1; ECE-1a; ECE-1b; ECE-1d; AW322500
UniProt Protein Name
Endothelin-converting enzyme 1
Protein Family
Endothelin-converting enzyme
UniProt Gene Name
Ece1
UniProt Synonym Gene Names
ECE-1
NCBI Protein Information
endothelin-converting enzyme 1

UniProt Comments for ECE1

ECE1: Converts big endothelin-1 to endothelin-1. Defects in ECE1 are a cause of Hirschsprung disease cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction. Belongs to the peptidase M13 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; EC 3.4.24.71; Membrane protein, integral; Protease; Vesicle

Chromosomal Location of Human Ortholog: 4|4 D3

Cellular Component: cell surface; cytoplasmic vesicle; early endosome; endosome; external side of plasma membrane; Golgi apparatus; integral component of membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; secretory granule; vesicle

Molecular Function: endopeptidase activity; hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein homodimerization activity; zinc ion binding

Biological Process: apoptosis; ear development; embryonic digit morphogenesis; heart development; hormone catabolic process; peptide hormone processing; pharyngeal system development; positive regulation of cAMP biosynthetic process; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of receptor recycling; protein processing; proteolysis; regulation of blood pressure; response to hypoxia
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Research Articles on ECE1

1. It is a amyloid beta degrading enzyme and is expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ECE1 antibody

 Reference Product  PubMed Publications
 Edn1 antibody  >18 publications with ECE1 and Edn1
 Ednrb antibody  >17 publications with ECE1 and Ednrb
 Ednra antibody  >13 publications with ECE1 and Ednra
 Nkx2-5 antibody  >2 publications with ECE1 and Nkx2-5
 Nrtn antibody  >1 publications with ECE1 and Nrtn
 Kbp antibody  >1 publications with ECE1 and Kbp
 Nr4a1 antibody  >1 publications with ECE1 and Nr4a1

Pathways associated with anti-ECE1 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-ECE1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >76 publications with ECE1 and Cardiovascular Diseases
 Hypertension Antibodies  >37 publications with ECE1 and Hypertension
 Heart Diseases Antibodies  >29 publications with ECE1 and Heart Diseases
 Atherosclerosis Antibodies  >24 publications with ECE1 and Atherosclerosis
 Inflammation Antibodies  >20 publications with ECE1 and Inflammation
 Kidney Diseases Antibodies  >13 publications with ECE1 and Kidney Diseases
 Necrosis Antibodies  >11 publications with ECE1 and Necrosis
 Carcinoma Antibodies  >11 publications with ECE1 and Carcinoma
 Hirschsprung Disease Antibodies  >10 publications with ECE1 and Hirschsprung Disease
 Lung Diseases Antibodies  >10 publications with ECE1 and Lung Diseases

Organs/Tissues associated with anti-ECE1 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >41 publications with ECE1 and Heart
 Embryonic Tissue Antibodies  >33 publications with ECE1 and Embryonic Tissue
 Kidney Antibodies  >30 publications with ECE1 and Kidney
 Brain Antibodies  >26 publications with ECE1 and Brain
 Lung Antibodies  >21 publications with ECE1 and Lung
 Ovary Antibodies  >17 publications with ECE1 and Ovary
 Skin Antibodies  >11 publications with ECE1 and Skin
 Liver Antibodies  >8 publications with ECE1 and Liver
 Intestine Antibodies  >7 publications with ECE1 and Intestine
 Eye Antibodies  >7 publications with ECE1 and Eye
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