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Selectin, Platelet (SELP) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002522
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MBS2002522 is an antibody targeting SELP. Also known as Biotin-Linked Antibody to Selectin, Platelet (SELP). Reactive in Mouse, Rat. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Selectin, Platelet (SELP), Polyclonal Antibody
Full Product Name
Biotin-Linked Antibody to Selectin, Platelet (SELP)
Product Gene Name
anti-SELP antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against SELP conjugated to biotin. It has been selected for its ability to recognize SELP in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Biotin Conjugated Antibody: SELP (MBS2002522)
Immunogen: SELP (MBS2011639)
Matching Pairs
Unconjugated Antibody: SELP (MBS2004172)
Biotin Conjugated Antibody: SELP (MBS2002522)
Molecular Weight
83,517 Da
Chromosome Location
Chromosome: 13; NC_005112.3 (87308435..87344164). Location: 13q22
3D Structure
ModBase 3D Structure for P98106
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Product Categories/Family for anti-SELP antibody

Biotin Antibody
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-SELP antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-SELP antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Other Notes

Small volumes of anti-SELP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SELP. It may not necessarily be applicable to this product.

NCBI GI #
149058205
NCBI GeneID
25651
NCBI Accession #
EDM09362.1
UniProt Primary Accession #
P98106
UniProt Related Accession #
P98106
NCBI Official Full Name
selectin, platelet
NCBI Official Synonym Full Names
selectin P
NCBI Official Symbol
Selp
NCBI Official Synonym Symbols
PSELECT
UniProt Protein Name
P-selectin
UniProt Synonym Protein Names
CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein
Protein Family
P-selectin
UniProt Gene Name
Selp
UniProt Synonym Gene Names
GMP-140; LECAM3; PADGEM
UniProt Entry Name
LYAM3_RAT
NCBI Protein Information
P-selectin; LECAM3; PADGEM; GMP-140; selectin, platelet; granule membrane protein 140; CD62 antigen-like family member P; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein

NCBI Summary for SELP

mediates leukocyte interaction with platelets and endothelial binding after vascular injury; may play a role in inflammatory response [RGD, Feb 2006]

UniProt Comments for SELP

Function: Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1

By similarity.

Subunit structure: Interacts with SNX17. Interacts with PSGL1/SEPL and PODXL2 and mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed in all tissues examined: spleen, lung, brain, liver, heart, kidney, thymus and small intestine.

Induction: By acute inflammation

Probable.

Sequence similarities: Belongs to the selectin/LECAM family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 8 Sushi (CCP/SCR) domains.
Show more

Research Articles on SELP

1. Aortic cyclooxygenase-2 and P-selectin were significantly down-regulated in plant sterols and plant sterols + tripeptides groups.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SELP antibody

 Reference Product  PubMed Publications
 Sell antibody  >20 publications with SELP and Sell
 Itgam antibody  >5 publications with SELP and Itgam
 Selplg antibody  >5 publications with SELP and Selplg
 Cd34 antibody  >4 publications with SELP and Cd34
 Cd63 antibody  >2 publications with SELP and Cd63
 Cd4 antibody  >1 publications with SELP and Cd4

Pathways associated with anti-SELP antibody

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with anti-SELP antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >60 publications with SELP and Cardiovascular Diseases
 Inflammation Antibodies  >33 publications with SELP and Inflammation
 Heart Diseases Antibodies  >26 publications with SELP and Heart Diseases
 Myocardial Ischemia Antibodies  >23 publications with SELP and Myocardial Ischemia
 Atherosclerosis Antibodies  >20 publications with SELP and Atherosclerosis
 Neoplasms Antibodies  >18 publications with SELP and Neoplasms
 Thrombosis Antibodies  >14 publications with SELP and Thrombosis
 Necrosis Antibodies  >9 publications with SELP and Necrosis
 Myocardial Infarction Antibodies  >8 publications with SELP and Myocardial Infarction
 Stroke Antibodies  >7 publications with SELP and Stroke

Organs/Tissues associated with anti-SELP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >102 publications with SELP and Blood
 Ovary Antibodies  >1 publications with SELP and Ovary
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