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Carcinoembryonic Antigen (CEA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002531
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MBS2002531 is an antibody targeting CEA. Also known as Polyclonal Antibody to Carcinoembryonic Antigen (CEA). Reactive in Homo sapiens (Human). Host: Rabbit. More details

$165 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Carcinoembryonic Antigen (CEA), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Carcinoembryonic Antigen (CEA)
Product Gene Name
anti-CEA antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Homo sapiens (Human)
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
0.5mg/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 24 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: CEA (MBS2002531)
Immunogen: CEA (MBS2010984)
Matching Pairs
Unconjugated Antibody: CEA (MBS2002531)
APC-CY7 Conjugated Antibody: CEA (MBS2038848)
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OMIM
M17303 Genomic DNA
3D Structure
ModBase 3D Structure for P06731
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant CEA (Ala566~Gly698) expressed in E.coli (MBS2010984).
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CEA antibody
Western Blot (WB)
Application Notes for anti-CEA antibody
Western blotting: 0.01-2ug/mL;
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-CEA antibody

Western Blot;
Sample: Human Serum;
Primary Ab: 1ug/ml Rabbit Anti-Human CEA Antibody
Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: MBS2086047)
Rabbit Anti-CEA Polyclonal Antibody – Cat# MBS2002531

Western Blot (WB) of anti-CEA antibody

Western Blot:
Sample: Recombinant protein.
Rabbit Anti-CEA Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002531

Immunohistochemistry (IHC) of anti-CEA antibody

DAB staining on IHC-P.
Samples: Human Tissue
Rabbit Anti-CEA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002531

Other Notes

Small volumes of anti-CEA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CEA. It may not necessarily be applicable to this product.

NCBI GI #
612407802
NCBI GeneID
1048
NCBI Accession #
NP_001278413.1
UniProt Primary Accession #
P06731
UniProt Secondary Accession #
H9KVA7
UniProt Related Accession #
P06731
GenBank Nucleotide #
NM_001291484.2
NCBI Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein
NCBI Official Synonym Full Names
carcinoembryonic antigen related cell adhesion molecule 5
NCBI Official Symbol
CEACAM5
NCBI Official Synonym Symbols
CEA; CD66e
UniProt Protein Name
Carcinoembryonic antigen-related cell adhesion molecule 5
UniProt Synonym Protein Names
Carcinoembryonic antigen; CEA; Meconium antigen 100; CD_antigen: CD66e
Protein Family
Colicin
UniProt Gene Name
CEACAM5
UniProt Synonym Gene Names
CEA; CEA
NCBI Protein Information
carcinoembryonic antigen-related cell adhesion molecule 5

NCBI Summary for CEA

This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
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UniProt Comments for CEA

CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family.

Protein type: Immunoglobulin superfamily; Membrane protein, GPI anchor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: basolateral plasma membrane; extracellular region; integral component of plasma membrane; plasma membrane

Molecular Function: identical protein binding; protein homodimerization activity

Biological Process: C-terminal protein lipidation; homotypic cell-cell adhesion; leukocyte migration; negative regulation of apoptosis
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Research Articles on CEA

1. This is the first population-based investigation of a large cohort of exclusively stage I rectal cancer patients providing compelling evidence that elevated preoperative CEA level is a strong predictor of worse overall and cancer-specific survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CEA antibody

 Reference Product  PubMed Publications
 CEACAM6 antibody  >115 publications with CEA and CEACAM6
 HNRNPM antibody  >3 publications with CEA and HNRNPM
 RAB11A antibody  >1 publications with CEA and RAB11A
 VPS33B antibody  >1 publications with CEA and VPS33B
 VIPAR antibody  >1 publications with CEA and VIPAR

Diseases associated with anti-CEA antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >8391 publications with CEA and Carcinoma
 Adenocarcinoma Antibodies  >4805 publications with CEA and Adenocarcinoma
 Liver Neoplasms Antibodies  >2575 publications with CEA and Liver Neoplasms
 Lung Neoplasms Antibodies  >2207 publications with CEA and Lung Neoplasms
 Liver Diseases Antibodies  >1954 publications with CEA and Liver Diseases
 Lung Diseases Antibodies  >1927 publications with CEA and Lung Diseases
 Breast Neoplasms Antibodies  >1686 publications with CEA and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1068 publications with CEA and Carcinoma, Squamous Cell
 Ovarian Neoplasms Antibodies  >833 publications with CEA and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >674 publications with CEA and Neoplasms, Experimental

Organs/Tissues associated with anti-CEA antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2401 publications with CEA and Lung
 Stomach Antibodies  >1302 publications with CEA and Stomach
 Thyroid Antibodies  >716 publications with CEA and Thyroid
 Intestine Antibodies  >707 publications with CEA and Intestine
 Pancreas Antibodies  >600 publications with CEA and Pancreas
 Kidney Antibodies  >346 publications with CEA and Kidney
 Ovary Antibodies  >340 publications with CEA and Ovary
 Muscle Antibodies  >298 publications with CEA and Muscle
 Brain Antibodies  >292 publications with CEA and Brain
 Cervix Antibodies  >260 publications with CEA and Cervix
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