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Collagen Type XVIII (COL18) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002541
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MBS2002541 is an antibody targeting COL18. Also known as Polyclonal Antibody to Collagen Type XVIII (COL18). Reactive in Mouse. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Collagen Type XVIII (COL18), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Collagen Type XVIII (COL18)
Product Gene Name
anti-COL18 antibody
Immunogen Sequence
Antigen: The target protein is fused with a His-tag and its sequence is listed below.
MGHHHHHHSG SEF-HTHQDF QPVL HLVALNTPLS GGMRGIRGAD FQCFQQARAV GLSGTFRAFL SSRLQDLYSI VRRADRGSVP IVNLKDEVLS PSWDSLFSGS QGQLQPGARI FSFDGRDVLR HPAWPQKSVW HGSDPSGRRL MESYCETWRT ETTGATGQAS SLLSGRLLEQ KAASCHNSYI VLCIENSFMT SFSK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against COL18. It has been selected for its ability to recognize COL18 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: COL18 (MBS2002541)
Biotin Conjugated Antibody: COL18 (MBS2004666)
Matching Pairs
Unconjugated Antibody: COL18 (MBS2002541)
Immunogen: COL18 (MBS2010509)
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Molecular Weight
134,204 Da
3D Structure
ModBase 3D Structure for P39061
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant COL18 (His1591~Lys1774) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2063498
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-COL18 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-COL18 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-COL18 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-COL18 Polyclonal Antibody – Cat# MBS2002541

Immunohistochemistry (IHC) of anti-COL18 antibody

DAB staining on fromalin fixed paraffin-embedded Liver tissue)
Rabbit Anti-COL18 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002541

Other Notes

Small volumes of anti-COL18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for COL18. It may not necessarily be applicable to this product.

NCBI GI #
158508560
NCBI GeneID
12822
NCBI Accession #
NP_001103461.1
UniProt Primary Accession #
P39061
UniProt Secondary Accession #
Q60672; Q61434; Q61437; Q62001; Q62002; Q6NZK9; Q6P1Y4; Q8CCZ8; Q9CRT2; Q9JK63
UniProt Related Accession #
P39061
GenBank Nucleotide #
NM_001109991.1
NCBI Official Full Name
collagen alpha-1(XVIII) chain isoform 1
NCBI Official Synonym Full Names
collagen, type XVIII, alpha 1
NCBI Official Symbol
Col18a1
UniProt Protein Name
Collagen alpha-1(XVIII) chain
UniProt Gene Name
Col18a1
UniProt Synonym Gene Names
NC1
NCBI Protein Information
collagen alpha-1(XVIII) chain

UniProt Comments for COL18

COL18A1: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1). An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele. Belongs to the multiplexin collagen family. 3 isoforms of the human protein are produced by alternative promoter.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM

Cellular Component: basement membrane; collagen; extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: metal ion binding; structural molecule activity

Biological Process: angiogenesis; cell adhesion; endothelial cell morphogenesis; extracellular matrix organization; positive regulation of cell migration; positive regulation of cell proliferation
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Research Articles on COL18

1. This study examined the staining levels of proteasomal and autophagy markers in the RPE of different ages of the Col18a1 (-/-) mice. Eyes from 3, 6-7, 10-13 and 18 months old mice were enucleated and embedded in paraffin according to the routine protocol.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-COL18 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Laminin Interactions Pathway antibodies  Laminin Interactions Pathway Diagram
 PodNet: Protein-protein Interactions In The Podocyte Pathway antibodies  PodNet: Protein-protein Interactions In The Podocyte Pathway Diagram

Diseases associated with anti-COL18 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >150 publications with COL18 and Lung Neoplasms
 Liver Neoplasms Antibodies  >119 publications with COL18 and Liver Neoplasms
 Liver Diseases Antibodies  >116 publications with COL18 and Liver Diseases
 Neoplasm Metastasis Antibodies  >103 publications with COL18 and Neoplasm Metastasis
 Brain Diseases Antibodies  >71 publications with COL18 and Brain Diseases
 Breast Neoplasms Antibodies  >54 publications with COL18 and Breast Neoplasms
 Necrosis Antibodies  >52 publications with COL18 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >51 publications with COL18 and Carcinoma, Hepatocellular
 Liver Neoplasms, Experimental Antibodies  >48 publications with COL18 and Liver Neoplasms, Experimental
 Kidney Diseases Antibodies  >47 publications with COL18 and Kidney Diseases

Organs/Tissues associated with anti-COL18 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >212 publications with COL18 and Lung
 Liver Antibodies  >164 publications with COL18 and Liver
 Eye Antibodies  >130 publications with COL18 and Eye
 Embryonic Tissue Antibodies  >98 publications with COL18 and Embryonic Tissue
 Brain Antibodies  >83 publications with COL18 and Brain
 Kidney Antibodies  >81 publications with COL18 and Kidney
 Muscle Antibodies  >69 publications with COL18 and Muscle
 Bone Antibodies  >62 publications with COL18 and Bone
 Skin Antibodies  >53 publications with COL18 and Skin
 Heart Antibodies  >41 publications with COL18 and Heart
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