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Interferon Beta (IFNb) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002551
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MBS2002551 is an antibody targeting IFNb. Also known as Polyclonal Antibody to Interferon Beta (IFNb). Reactive in Horse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Interferon Beta (IFNb), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Interferon Beta (IFNb)
Product Gene Name
anti-IFNb antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-VNY DLLRSQ LRSSNSACLM LLRQLNGAPQ RCPEDTMNFQ VPEEIEQAQQ FQKEDAALVI YEMLQHTWRI FRRNFASTGW NETIVKNLLV EVHLQMDRLE TNLEEIMEEE SSTWGNTTIL RLKKYYGRIS QYLKAKKYSH CAWTVVQAEM LRNLAFLNGL TDYLQN
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Horse
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against IFNb. It has been selected for its ability to recognize IFNb in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Molecular Weight
22,294 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (21077104..21077943, complement). Location: 9p21
OMIM
147640
3D Structure
ModBase 3D Structure for P01574
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant IFNb (Val22~Asn186) expressed in E.coli.
Cross Reactivity
Horse
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-IFNb antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-IFNb antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-IFNb antibody

(Figure. Western Blot; Sample: Recombinant protein.)
Rabbit Anti-IFNb Polyclonal Antibody – Cat# MBS2002551

Other Notes

Small volumes of anti-IFNb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNb. It may not necessarily be applicable to this product.

NCBI GI #
4504603
NCBI GeneID
3456
NCBI Accession #
NP_002167.1
UniProt Primary Accession #
P01574
UniProt Related Accession #
P01574
GenBank Nucleotide #
NM_002176.2
NCBI Official Full Name
interferon beta
NCBI Official Synonym Full Names
interferon, beta 1, fibroblast
NCBI Official Symbol
IFNB1
NCBI Official Synonym Symbols
IFB; IFF; IFNB
UniProt Protein Name
Interferon beta
UniProt Synonym Protein Names
Fibroblast interferon
Protein Family
Interferon
UniProt Gene Name
IFNB1
UniProt Synonym Gene Names
IFB; IFNB; IFN-beta
UniProt Entry Name
IFNB_HUMAN
NCBI Protein Information
interferon beta; IFN-beta; fibroblast interferon

UniProt Comments for IFNb

IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: extracellular space; extracellular region

Molecular Function: interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; response to virus; cytokine and chemokine mediated signaling pathway; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; cell surface receptor linked signal transduction; response to exogenous dsRNA; negative regulation of viral genome replication; B cell differentiation; positive regulation of innate immune response; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; B cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein
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Research Articles on IFNb

1. Herpes simplex virus 1 US3 hyperphosphorylates IRF3 and inhibits beta interferon production.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IFNb antibody

 Reference Product  PubMed Publications
 IRF3 antibody  >12 publications with IFNb and IRF3
 IFNAR1 antibody  >4 publications with IFNb and IFNAR1
 IRF7 antibody  >3 publications with IFNb and IRF7
 STAT2 antibody  >2 publications with IFNb and STAT2
 EP300 antibody  >1 publications with IFNb and EP300
 CREBBP antibody  >1 publications with IFNb and CREBBP
 IRF1 antibody  >1 publications with IFNb and IRF1
 IFNAR2 antibody  >1 publications with IFNb and IFNAR2

Pathways associated with anti-IFNb antibody

 Products by Pathway  Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram

Diseases associated with anti-IFNb antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >4 publications with IFNb and Necrosis
 Inflammation Antibodies  >4 publications with IFNb and Inflammation
 Carcinoma Antibodies  >4 publications with IFNb and Carcinoma
 Lung Neoplasms Antibodies  >2 publications with IFNb and Lung Neoplasms
 Multiple Sclerosis Antibodies  >2 publications with IFNb and Multiple Sclerosis
 Melanoma Antibodies  >2 publications with IFNb and Melanoma
 Cardiovascular Diseases Antibodies  >2 publications with IFNb and Cardiovascular Diseases
 Brain Diseases Antibodies  >2 publications with IFNb and Brain Diseases
 Neoplasms, Experimental Antibodies  >1 publications with IFNb and Neoplasms, Experimental
 Pancreatic Neoplasms Antibodies  >1 publications with IFNb and Pancreatic Neoplasms
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