Laminin Alpha 1 (LAMa1) Antibody – Rabbit Polyclonal

This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]

LAMA1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 18p11.31

Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; laminin-1 complex; laminin-3 complex; membrane; proteinaceous extracellular matrix

Molecular Function: extracellular matrix structural constituent; protein binding; protein C-terminus binding; receptor binding

Biological Process: cell adhesion; cell surface receptor signaling pathway; extracellular matrix organization; regulation of cell adhesion; regulation of cell migration; regulation of embryonic development

Disease: Poretti-boltshauser Syndrome