Protein Kinase C Epsilon (PKCe) Antibody – Rabbit Polyclonal

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

PKCE: an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction.

Protein type: AGC group; EC 2.7.11.13; Eta subfamily; Kinase, protein; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: cell periphery; cytoplasm; cytoskeleton; cytosol; endoplasmic reticulum; Golgi apparatus; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: 14-3-3 protein binding; actin monomer binding; ATP binding; calcium-independent protein kinase C activity; enzyme activator activity; enzyme binding; ethanol binding; metal ion binding; protein binding; protein kinase C activity; protein serine/threonine kinase activity; receptor activator activity; signal transducer activity

Biological Process: apoptosis; cell adhesion; cell cycle; cell division; cellular response to ethanol; cellular response to hypoxia; cellular response to prostaglandin E stimulus; Fc-gamma receptor signaling pathway involved in phagocytosis; lipopolysaccharide-mediated signaling pathway; macrophage activation involved in immune response; negative regulation of protein ubiquitination; negative regulation of sodium ion transmembrane transporter activity; peptidyl-serine phosphorylation; platelet activation; positive regulation of actin filament polymerization; positive regulation of catalytic activity; positive regulation of cell-substrate adhesion; positive regulation of cellular glucuronidation; positive regulation of cytokinesis; positive regulation of epithelial cell migration; positive regulation of fibroblast migration; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of insulin secretion; positive regulation of lipid catabolic process; positive regulation of MAPK cascade; positive regulation of receptor activity; positive regulation of synaptic transmission, GABAergic; positive regulation of wound healing; protein amino acid phosphorylation; regulation of peptidyl-tyrosine phosphorylation; regulation of release of sequestered calcium ion into cytosol; release of sequestered calcium ion into cytosol; response to morphine; signal transduction