Cluster of Differentiation 34 (CD34) Antibody – Rabbit Polyclonal

The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

CD34: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Belongs to the CD34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: apical plasma membrane; basal plasma membrane; cytoplasm; external side of plasma membrane; integral component of plasma membrane; intercellular bridge; lysosome; perinuclear region of cytoplasm; plasma membrane

Molecular Function: carbohydrate binding; sulfate binding; transcription factor binding

Biological Process: cell motility; cell proliferation; cell-matrix adhesion; endothelial cell proliferation; endothelium development; extracellular exosome assembly; glomerular endothelium development; glomerular filtration; hematopoietic stem cell proliferation; hemopoiesis; leukocyte migration; metanephric glomerular mesangial cell differentiation; negative regulation of blood coagulation; negative regulation of cellular response to heat; negative regulation of cellular response to hypoxia; negative regulation of gene expression; negative regulation of interleukin-2 secretion; negative regulation of neuron death; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor production; paracrine signaling; positive regulation of angiogenesis; positive regulation of gene expression; positive regulation of glial cell-derived neurotrophic factor secretion; positive regulation of granulocyte colony-stimulating factor production; positive regulation of interleukin-10 production; positive regulation of odontogenesis; positive regulation of transforming growth factor beta production; positive regulation of vasculogenesis; regulation of blood pressure; regulation of immune response; signal transduction; stem cell proliferation; tissue homeostasis