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Colony Stimulating Factor 2 Receptor Beta (CSF2Rb) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002598
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MBS2002598 is an antibody targeting CSF2Rb. Also known as Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Beta (CSF2Rb). Reactive in Human. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Colony Stimulating Factor 2 Receptor Beta (CSF2Rb), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Colony Stimulating Factor 2 Receptor Beta (CSF2Rb)
Product Gene Name
anti-CSF2Rb antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF - PPEPRDLQ ISTDQDHFLL TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD SWEDAAILLS NTSQATLGPE HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEV
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against CSF2Rb. It has been selected for its ability to recognize CSF2Rb in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: CSF2Rb (MBS2002598)
Immunogen: CSF2Rb (MBS2010271)
Matching Pairs
Unconjugated Antibody: CSF2Rb (MBS2002598)
APC-CY7 Conjugated Antibody: CSF2Rb (MBS2056270)
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Molecular Weight
97,976 Da
OMIM
M59941 mRNA
3D Structure
ModBase 3D Structure for P32927
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant CSF2Rb (Pro133~Val233) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2056272
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CSF2Rb antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-CSF2Rb antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-CSF2Rb antibody

Western Blot: Sample: Recombinant CSF2Rb, Human.
Rabbit Anti-CSF2Rb Polyclonal Antibody – Cat# MBS2002598

Immunohistochemistry (IHC) of anti-CSF2Rb antibody

DAB staining on IHC-P; Samples: Human Endometrial cancer Tissue)
Rabbit Anti-CSF2Rb Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002598

Other Notes

Small volumes of anti-CSF2Rb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CSF2Rb. It may not necessarily be applicable to this product.

NCBI GI #
4559408
NCBI GeneID
1439
NCBI Accession #
NP_000386.1
UniProt Primary Accession #
P32927
UniProt Secondary Accession #
Q5JZI1; Q6ICE0
UniProt Related Accession #
P32927
GenBank Nucleotide #
NM_000395.2
NCBI Official Full Name
cytokine receptor common subunit beta
NCBI Official Synonym Full Names
colony stimulating factor 2 receptor beta common subunit
NCBI Official Symbol
CSF2RB
NCBI Official Synonym Symbols
CD131; IL3RB; IL5RB; SMDP5; CDw131; betaGMR
UniProt Protein Name
Cytokine receptor common subunit beta
UniProt Synonym Protein Names
CDw131; GM-CSF/IL-3/IL-5 receptor common beta subunit; CD_antigen: CD131
Protein Family
Cytokine receptor
UniProt Gene Name
CSF2RB
UniProt Synonym Gene Names
IL3RB; IL5RB
NCBI Protein Information
cytokine receptor common subunit beta

NCBI Summary for CSF2Rb

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

UniProt Comments for CSF2Rb

CSF2RB: a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. A type I cytokine family of receptor. Defects are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: granulocyte macrophage colony-stimulating factor receptor complex; integral component of plasma membrane; intracellular; plasma membrane

Molecular Function: interleukin-3 receptor activity; interleukin-5 receptor activity; protein binding; protein tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity

Biological Process: cellular protein metabolic process; interleukin-3-mediated signaling pathway; interleukin-5-mediated signaling pathway; MAPK cascade; peptidyl-tyrosine phosphorylation; regulation of molecular function; respiratory gaseous exchange; response to lipopolysaccharide; signal transduction

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 5
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Research Articles on CSF2Rb

1. SYK mediates the actions of EPO and GM-CSF and coordinates with TGF-beta in erythropoiesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CSF2Rb antibody

 Reference Product  PubMed Publications
 IL5RA antibody  >37 publications with CSF2Rb and IL5RA
 JAK2 antibody  >24 publications with CSF2Rb and JAK2
 JAK1 antibody  >15 publications with CSF2Rb and JAK1
 IL3 antibody  >10 publications with CSF2Rb and IL3
 STAT1 antibody  >10 publications with CSF2Rb and STAT1
 IL3RA antibody  >8 publications with CSF2Rb and IL3RA
 STAT3 antibody  >8 publications with CSF2Rb and STAT3
 EPOR antibody  >7 publications with CSF2Rb and EPOR
 CSF2 antibody  >7 publications with CSF2Rb and CSF2
 CSF2RA antibody  >5 publications with CSF2Rb and CSF2RA

Pathways associated with anti-CSF2Rb antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-5 Signaling Pathway antibodies  IL-5 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin Receptor SHC Signaling Pathway antibodies  Interleukin Receptor SHC Signaling Pathway Diagram
 Interleukin-2 Signaling Pathway antibodies  Interleukin-2 Signaling Pathway Diagram

Diseases associated with anti-CSF2Rb antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >30 publications with CSF2Rb and Neoplasms
 Inflammation Antibodies  >26 publications with CSF2Rb and Inflammation
 Lung Diseases Antibodies  >14 publications with CSF2Rb and Lung Diseases
 Necrosis Antibodies  >9 publications with CSF2Rb and Necrosis
 Neoplasms, Experimental Antibodies  >4 publications with CSF2Rb and Neoplasms, Experimental
 Fibrosis Antibodies  >3 publications with CSF2Rb and Fibrosis
 Colitis Antibodies  >3 publications with CSF2Rb and Colitis
 Liver Diseases Antibodies  >3 publications with CSF2Rb and Liver Diseases
 Heart Diseases Antibodies  >3 publications with CSF2Rb and Heart Diseases
 Drug Toxicity Antibodies  >2 publications with CSF2Rb and Drug Toxicity

Organs/Tissues associated with anti-CSF2Rb antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >103 publications with CSF2Rb and Blood
 Bone Antibodies  >23 publications with CSF2Rb and Bone
 Bone Marrow Antibodies  >21 publications with CSF2Rb and Bone Marrow
 Lung Antibodies  >18 publications with CSF2Rb and Lung
 Vascular Antibodies  >12 publications with CSF2Rb and Vascular
 Brain Antibodies  >11 publications with CSF2Rb and Brain
 Skin Antibodies  >8 publications with CSF2Rb and Skin
 Intestine Antibodies  >5 publications with CSF2Rb and Intestine
 Lymph Node Antibodies  >4 publications with CSF2Rb and Lymph Node
 Muscle Antibodies  >3 publications with CSF2Rb and Muscle
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