Neuropilin 1 (NRP1) Antibody – Rabbit Polyclonal

NRP1: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 8 E2|8 75.78 cM

Cellular Component: axon; cell soma; cell surface; cytosol; early endosome; extracellular space; focal adhesion; growth cone; integral component of membrane; membrane; neurofilament; plasma membrane

Molecular Function: growth factor binding; GTPase activator activity; heparin binding; metal ion binding; protein binding; semaphorin receptor activity; vascular endothelial growth factor binding; vascular endothelial growth factor-activated receptor activity

Biological Process: actin cytoskeleton reorganization; angiogenesis; artery morphogenesis; axon extension involved in axon guidance; axon guidance; axonal fasciculation; branching involved in blood vessel morphogenesis; branchiomotor neuron axon guidance; cardiac neural crest cell migration involved in outflow tract morphogenesis; cell differentiation; cell migration; cell migration during sprouting angiogenesis; commissural neuron axon guidance; dendrite development; dorsal root ganglion morphogenesis; endothelial cell migration; facial nerve structural organization; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; heart development; hepatocyte growth factor receptor signaling pathway; integrin-mediated signaling pathway; motor axon guidance; multicellular organism development; negative regulation of axon extension; negative regulation of axon extension involved in axon guidance; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of neuron apoptosis; nerve development; nervous system development; neural crest cell migration involved in autonomic nervous system development; neuron development; neuron migration; neuropilin signaling pathway; organ morphogenesis; otic placode development; outflow tract septum morphogenesis; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of actin cytoskeleton reorganization; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of filopodium formation; positive regulation of focal adhesion assembly; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphorylation; positive regulation of retinal ganglion cell axon guidance; positive regulation of stress fiber formation; positive regulation of substrate adhesion-dependent cell spreading; regulation of axon extension involved in axon guidance; regulation of Cdc42 protein signal transduction; regulation of retinal ganglion cell axon guidance; retinal ganglion cell axon guidance; semaphorin-plexin signaling pathway; semaphorin-plexin signaling pathway involved in axon guidance; semaphorin-plexin signaling pathway involved in neuron projection guidance; sprouting angiogenesis; substrate-dependent cell migration, cell extension; sympathetic nervous system development; toxin transport; trigeminal nerve morphogenesis; trigeminal nerve structural organization; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; VEGF-activated neuropilin signaling pathway; ventral trunk neural crest cell migration; vestibulocochlear nerve structural organization