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Interleukin 22 Receptor (IL22R) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002652
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MBS2002652 is an antibody targeting IL22R. Also known as Polyclonal Antibody to Interleukin 22 Receptor (IL22R). Reactive in Human, Mouse, Rat, Pig. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin 22 Receptor (IL22R), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Interleukin 22 Receptor (IL22R)
Product Gene Name
anti-IL22R antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-QRV L TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS YAPNAAPEVG PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP PSYGVCMEGS GKDSPTGTLS SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV TSLAMEESQE AKSLHQPLGI CTDRTSDPNV LHSGEEGTPQ YLKGQLPLLS SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK DEAKSPAPET SDLEQPTELD SLFRG
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Pig
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against IL22R. It has been selected for its ability to recognize IL22R in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: IL22R (MBS2002652)
Immunogen: IL22R (MBS2009308)
Matching Pairs
Unconjugated Antibody: IL22R (MBS2002652)
APC-CY7 Conjugated Antibody: IL22R (MBS2075275)
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Molecular Weight
63,077 Da
OMIM
AF286095 mRNA
3D Structure
ModBase 3D Structure for Q8N6P7
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant IL22R (Gln267~Gly565) expressed in E.coli.
Cross Reactivity
Human, Pig
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2075277
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-IL22R antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-IL22R antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-IL22R antibody

Western Blot: Sample: Lane1: Porcine Spleen Tissue; Lane2: Human K562 Cell.
Rabbit Anti-IL22R Polyclonal Antibody – Cat# MBS2002652

Western Blot (WB) of anti-IL22R antibody

Western Blot: Sample: Recombinant IL22R, Human.
Rabbit Anti-IL22R Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002652

Immunohistochemistry (IHC) of anti-IL22R antibody

DAB staining on IHC-P. Samples: Human Tissue)
Rabbit Anti-IL22R Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002652

Other Notes

Small volumes of anti-IL22R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL22R. It may not necessarily be applicable to this product.

NCBI GI #
31317239
NCBI GeneID
58985
NCBI Accession #
NP_067081.2
UniProt Primary Accession #
Q8N6P7
UniProt Secondary Accession #
Q9HB22; A8K839; B2R9Y9
UniProt Related Accession #
Q8N6P7
GenBank Nucleotide #
NM_021258.3
NCBI Official Full Name
interleukin-22 receptor subunit alpha-1
NCBI Official Synonym Full Names
interleukin 22 receptor subunit alpha 1
NCBI Official Symbol
IL22RA1
NCBI Official Synonym Symbols
IL22R; CRF2-9; IL22R1
UniProt Protein Name
Interleukin-22 receptor subunit alpha-1
UniProt Synonym Protein Names
Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; CRF2-9; ZcytoR11
UniProt Gene Name
IL22RA1
UniProt Synonym Gene Names
IL22R; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; CRF2-9
NCBI Protein Information
interleukin-22 receptor subunit alpha-1

NCBI Summary for IL22R

The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL22R

IL22RA1: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: integral component of membrane; plasma membrane

Molecular Function: interferon receptor activity; interleukin-20 binding; protein binding

Biological Process: cytokine-mediated signaling pathway; defense response to Gram-negative bacterium
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Research Articles on IL22R

1. increased expression of IL-22Ralpha therefore promotes keratinocyte proliferation and pro-inflammatory cytokine production during UVB-induced skin inflammation, suggesting that UVB facilitates skin inflammation by increasing the responsiveness of keratinocytes to IL-22

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL22R antibody

 Reference Product  PubMed Publications
 IL22 antibody  >4 publications with IL22R and IL22
 IL20 antibody  >2 publications with IL22R and IL20
 IL24 antibody  >2 publications with IL22R and IL24
 IL10RB antibody  >2 publications with IL22R and IL10RB

Pathways associated with anti-IL22R antibody

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL22R antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with IL22R and Neoplasms
 Disease Models, Animal Antibodies  >1 publications with IL22R and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >1 publications with IL22R and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >1 publications with IL22R and Breast Neoplasms
 Immune System Diseases Antibodies  >1 publications with IL22R and Immune System Diseases
 Inflammation Antibodies  >1 publications with IL22R and Inflammation

Organs/Tissues associated with anti-IL22R antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with IL22R and Skin
 Thyroid Antibodies  >1 publications with IL22R and Thyroid
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