Nerve Growth Factor Inducible (VGF) Antibody – Rabbit Polyclonal

This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

VGF: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: cytoplasmic vesicle; endoplasmic reticulum lumen; extracellular space; intracellular membrane-bound organelle; transport vesicle

Molecular Function: growth factor activity; hormone activity; neuropeptide hormone activity

Biological Process: carbohydrate homeostasis; cellular protein metabolic process; defense response to bacterium; generation of precursor metabolites and energy; glucose homeostasis; insulin secretion; ovarian follicle development; post-translational protein modification; regulation of synaptic plasticity; response to cAMP; response to cold; response to dietary excess; response to insulin stimulus; sexual reproduction