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Left/Right Determination Factor 1 (LEFTY1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002667
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MBS2002667 is an antibody targeting LEFTY1. Also known as Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1). Reactive in Rat. Host: Rabbit. More details

$220 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Left/Right Determination Factor 1 (LEFTY1), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Left/Right Determination Factor 1 (LEFTY1)
Product Gene Name
anti-LEFTY1 antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -SI HESGWKVFDV TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP GTWSAHKLVR FAAQGTPDGK GLGEPQLELH TLDLKDYGAQ GNCDPETPVT EGTRCCRQEM YLDLQGMKWA ENWILEPPGF LTYECVGSCL QPPESLTIRW PFLGPRQCVA 　SE MTSLPLIV SIKEDGRTRP QVVSLPNMRV QRCSCASDGA LIPRRLEP
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against LEFTY1. It has been selected for its ability to recognize LEFTY1 in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: LEFTY1 (MBS2002667)
Biotin Conjugated Antibody: LEFTY1 (MBS2002514)
Matching Pairs
Unconjugated Antibody: LEFTY1 (MBS2002667)
Immunogen: LEFTY1 (MBS2009733)
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Molecular Weight
41,754 Da
3D Structure
ModBase 3D Structure for D4A670
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant LEFTY1 (Ser169~Pro368) expressed in E.coli.
Cross Reactivity
Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2063788
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-LEFTY1 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-LEFTY1 antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-LEFTY1 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-LEFTY1 Polyclonal Antibody – Cat# MBS2002667

Immunohistochemistry (IHC) of anti-LEFTY1 antibody

DABstainingonIHC-P.Samples:RatTissue)
Rabbit Anti-LEFTY1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002667

Other Notes

Small volumes of anti-LEFTY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LEFTY1. It may not necessarily be applicable to this product.

NCBI GI #
157818695
NCBI GeneID
498299
NCBI Accession #
NP_001102550.1
UniProt Primary Accession #
D4A670
GenBank Nucleotide #
NM_001109080.1
NCBI Official Full Name
left-right determination factor 1
NCBI Official Synonym Full Names
left right determination factor 1
NCBI Official Symbol
Lefty1
NCBI Official Synonym Symbols
RGD1561867
UniProt Protein Name
Left right determination factor 1
UniProt Synonym Protein Names
Left right determination factor 1
Protein Family
Left-right determination factor
UniProt Gene Name
Lefty1
NCBI Protein Information
left-right determination factor 1

UniProt Comments for LEFTY1

LEFTY1: Required for left-right axis determination as a regulator of LEFTY2 and NODAL. Belongs to the TGF-beta family.

Protein type: Cytokine; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13q26

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; transforming growth factor beta receptor binding

Biological Process: anterior/posterior axis specification; BMP signaling pathway; cell development; cell growth; cell migration involved in gastrulation; determination of left/right symmetry; heart morphogenesis; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of MAPK cascade; response to retinoic acid
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LEFTY1 antibody

 Reference Product  PubMed Publications
 Nodal antibody  >84 publications with LEFTY1 and Nodal
 Tgfb1 antibody  >4 publications with LEFTY1 and Tgfb1
 Tgfb3 antibody  >2 publications with LEFTY1 and Tgfb3

Pathways associated with anti-LEFTY1 antibody

 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with anti-LEFTY1 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >11 publications with LEFTY1 and Heart Diseases
 Embryo Loss Antibodies  >6 publications with LEFTY1 and Embryo Loss
 Fibrosis Antibodies  >4 publications with LEFTY1 and Fibrosis
 Infertility, Female Antibodies  >3 publications with LEFTY1 and Infertility, Female
 Disease Models, Animal Antibodies  >3 publications with LEFTY1 and Disease Models, Animal
 Breast Neoplasms Antibodies  >2 publications with LEFTY1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >2 publications with LEFTY1 and Nervous System Diseases
 Nervous System Malformations Antibodies  >2 publications with LEFTY1 and Nervous System Malformations
 Carcinoma Antibodies  >2 publications with LEFTY1 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >2 publications with LEFTY1 and Cell Transformation, Neoplastic
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