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Suppressor of Variegation 4-20 Homolog 2 (SUV420H2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002685
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2002685 is an antibody targeting SUV420H2. Also known as Polyclonal Antibody to Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2). Reactive in Mouse, Rat. Host: Rabbit. More details

$230 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Suppressor Of Variegation 4-20 Homolog 2 (SUV420H2)
Product Gene Name
anti-SUV420H2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
Purity/Purification
Antigen-specific Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a Rabbit polyclonal antibody raised against SUV420H2. It has been selected for its ability to recognize SUV420H2 in immunohistochemical staining and western blotting.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 4°C for frequent use.
Aliquot and store at -20°C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: SUV420H2 (MBS2002685)
Biotin Conjugated Antibody: SUV420H2 (MBS2003704)
Matching Pairs
Unconjugated Antibody: SUV420H2 (MBS2002685)
Immunogen: SUV420H2 (MBS2009739)
Show more
Molecular Weight
10,821 Da
OMIM
AC020922 Genomic DNA
3D Structure
ModBase 3D Structure for Q86Y97
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant SUV420H2 (Gly2~Leu279) expressed in E.coli
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2084011
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-SUV420H2 antibody
WB; IHC; ICC; IP
Application Notes for anti-SUV420H2 antibody
Western blotting: 0.5-2µg/mL
Immunohistochemistry: 5-20µg/mL
Immunocytochemistry: 5-20µg/mL

Optimal working dilutions must be determined by end user

Western Blot (WB) of anti-SUV420H2 antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-SUV420H2 Polyclonal Antibody – Cat# MBS2002685

Immunohistochemistry (IHC) of anti-SUV420H2 antibody

DAB staining on fromalin fixed paraffin-embedded Kidney tissue)
Rabbit Anti-SUV420H2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002685

Other Notes

Small volumes of anti-SUV420H2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SUV420H2. It may not necessarily be applicable to this product.

NCBI GI #
31543169
NCBI GeneID
84787
NCBI Accession #
NP_116090.2
UniProt Primary Accession #
Q86Y97
UniProt Secondary Accession #
Q8WZ10; Q9BRZ6
UniProt Related Accession #
Q86Y97
GenBank Nucleotide #
NM_032701.3
NCBI Official Full Name
histone-lysine N-methyltransferase KMT5C
NCBI Official Synonym Full Names
lysine methyltransferase 5C
NCBI Official Symbol
KMT5C
NCBI Official Synonym Symbols
SUV420H2; Suv4-20h2
UniProt Protein Name
Histone-lysine N-methyltransferase KMT5C
UniProt Synonym Protein Names
Lysine N-methyltransferase 5C; Lysine-specific methyltransferase 5C
UniProt Gene Name
KMT5C
UniProt Synonym Gene Names
Su(var)4-20 homolog 2; Suv4-20h2
NCBI Protein Information
histone-lysine N-methyltransferase KMT5C

NCBI Summary for SUV420H2

SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009]

UniProt Comments for SUV420H2

SUV420H2: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2). Belongs to the histone-lysine methyltransferase family. Suvar4-20 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: centric heterochromatin; condensed nuclear chromosome, centromeric region; nuclear heterochromatin; nucleoplasm

Molecular Function: histone lysine N-methyltransferase activity (H4-K20 specific); histone-lysine N-methyltransferase activity; protein binding

Biological Process: regulation of transcription, DNA-templated; transcription, DNA-dependent
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Research Articles on SUV420H2

1. Study provides evidence that Suv420h2 controls the H4K20 methylome of osteoblasts and is critical for normal progression of osteoblastogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SUV420H2 antibody

 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with anti-SUV420H2 antibody

 Disease Name  Pubmed Publications
 Hyperglycemia Antibodies  >1 publications with SUV420H2 and Hyperglycemia

Organs/Tissues associated with anti-SUV420H2 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1 publications with SUV420H2 and Eye
 Muscle Antibodies  >1 publications with SUV420H2 and Muscle
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