• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Transferrin Receptor (TFR) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002688
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2002688 is an antibody targeting TFR. Also known as Polyclonal Antibody to Transferrin Receptor (TFR). Reactive in Human. Host: Rabbit. More details

$210 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transferrin Receptor (TFR), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Transferrin Receptor (TFR)
Product Gene Name
anti-TFR antibody
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS EF- GTTM DTYKELIERI PELNKVARAA AEVAGQFVIK LTHDVELNLD YERYNSQLLS FVRDLNQYRA DIKEMGLSLQ WLYSARGDFF RATSRLTTDF GNAEKTDRFV MKKLNDRVMR VEYHFLSPYV SPKESPFRHV FWGSGSHTLP ALLENLKLRK QNNGAFNETL FRNQLALATW TIQG
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against TFR. It has been selected for its ability to recognize TFR in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: TFR (MBS2002688)
Biotin Conjugated Antibody: TFR (MBS2003842)
Matching Pairs
Unconjugated Antibody: TFR (MBS2002688)
Immunogen: TFR (MBS2009600)
Show more
Molecular Weight
84,871 Da
OMIM
X01060 mRNA
3D Structure
ModBase 3D Structure for P02786
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant TFR (Gly567~Gly744) expressed in E.coli.
Cross Reactivity
Human
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2052116
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-TFR antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-TFR antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-TFR antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-TFR Polyclonal Antibody – Cat# MBS2002688

Immunohistochemistry (IHC) of anti-TFR antibody

DAB staining on fromalin fixed paraffin- embedded brain tissue)
Rabbit Anti-TFR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002688

Other Notes

Small volumes of anti-TFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TFR. It may not necessarily be applicable to this product.

NCBI GI #
189458819
NCBI GeneID
7037
NCBI Accession #
NP_001121620.1
UniProt Primary Accession #
P02786
UniProt Secondary Accession #
Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0
UniProt Related Accession #
P02786
GenBank Nucleotide #
NM_001128148.2
NCBI Official Full Name
transferrin receptor protein 1 isoform 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
TFRC
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90; CD_antigen: CD71
UniProt Gene Name
TFRC
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR
NCBI Protein Information
transferrin receptor protein 1

NCBI Summary for TFR

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

UniProt Comments for TFR

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; blood microparticle; cell surface; clathrin-coated pit; clathrin-coated vesicle membrane; cytoplasmic vesicle; early endosome; endosome; endosome membrane; external side of plasma membrane; extracellular exosome; extracellular region; extracellular space; HFE-transferrin receptor complex; integral component of plasma membrane; melanosome; membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome

Molecular Function: double-stranded RNA binding; identical protein binding; protein binding; protein homodimerization activity; RNA binding; transferrin receptor activity; transferrin transmembrane transporter activity; viral receptor activity

Biological Process: cellular iron ion homeostasis; entry of virus into host cell; osteoclast differentiation; positive regulation of B cell proliferation; positive regulation of bone resorption; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; regulation of cell growth; regulation of cell proliferation; transferrin transport

Disease: Immunodeficiency 46
Show more

Research Articles on TFR

1. TfR1 was highly expressed in glioblastomas and associated with shorter survival in the whole cohort, but not in the individual malignancy grades

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TFR antibody

 Reference Product  PubMed Publications
 HFE antibody  >18 publications with TFR and HFE
 CD4 antibody  >1 publications with TFR and CD4

Pathways associated with anti-TFR antibody

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram

Diseases associated with anti-TFR antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with TFR and Neoplasms
 Iron Metabolism Disorders Antibodies  >28 publications with TFR and Iron Metabolism Disorders
 Anemia Antibodies  >16 publications with TFR and Anemia
 Disease Models, Animal Antibodies  >11 publications with TFR and Disease Models, Animal
 Anemia, Iron-Deficiency Antibodies  >8 publications with TFR and Anemia, Iron-Deficiency
 Lung Neoplasms Antibodies  >7 publications with TFR and Lung Neoplasms
 Liver Diseases Antibodies  >6 publications with TFR and Liver Diseases
 Brain Diseases Antibodies  >5 publications with TFR and Brain Diseases
 Breast Neoplasms Antibodies  >4 publications with TFR and Breast Neoplasms
 Drug Toxicity Antibodies  >4 publications with TFR and Drug Toxicity

Organs/Tissues associated with anti-TFR antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34 publications with TFR and Blood
 Liver Antibodies  >22 publications with TFR and Liver
 Brain Antibodies  >16 publications with TFR and Brain
 Intestine Antibodies  >11 publications with TFR and Intestine
 Lung Antibodies  >10 publications with TFR and Lung
 Bone Antibodies  >8 publications with TFR and Bone
 Skin Antibodies  >7 publications with TFR and Skin
 Kidney Antibodies  >7 publications with TFR and Kidney
 Embryonic Tissue Antibodies  >6 publications with TFR and Embryonic Tissue
 Prostate Antibodies  >5 publications with TFR and Prostate
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000