• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Cyclophilin B (CYPB) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2002713
SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment

MBS2002713 is an antibody targeting CYPB. Also known as Polyclonal Antibody to Cyclophilin B (CYPB). Reactive in Mouse, Rat. Host: Rabbit. More details

$205 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cyclophilin B (CYPB), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Cyclophilin B (CYPB)
Product Gene Name
anti-CYPB antibody
Immunogen Sequence
Antigen: The target protein is fused with a His-tag and its sequence is listed below.
MGHHHHHHSG SEF-NDKKKG P KVTVKVYFDL QIGDESVGRV VFGLFGKTVP KTVDNFVALA TGEKGFGYKN SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTS WLDGKHVVFG KVLEGMDVVR KVESTKTDSR DKPLKDVIIV DSGKIEVEKP FAIAKE
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
500ug/mL (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against CYPB. It has been selected for its ability to recognize CYPB in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: CYPB (MBS2002713)
Biotin Conjugated Antibody: CYPB (MBS2001986)
Matching Pairs
Unconjugated Antibody: CYPB (MBS2002713)
Immunogen: CYPB (MBS2009092)
Show more
Molecular Weight
23,713 Da
3D Structure
ModBase 3D Structure for P24369
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant CYPB (Asn34~Glu216) expressed in E.coli.
Cross Reactivity
Mouse
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2039883
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-CYPB antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-CYPB antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-CYPB antibody

Western Blot: Sample: Mouse Kidney lysate; Primary Ab: 1ug/ml Rabbit Anti-Mouse CYPB Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;
Rabbit Anti-CYPB Polyclonal Antibody – Cat# MBS2002713

Western Blot (WB) of anti-CYPB antibody

Western Blot: Sample: Mouse Serum; Primary Ab: 1ug/ml Rabbit Anti-Mouse CYPB Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047)
Rabbit Anti-CYPB Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002713

Western Blot (WB) of anti-CYPB antibody

Western Blot: Sample: Mouse Heart lysate; Primary Ab: 1ug/ml Rabbit Anti-Mouse CYPB Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047)
Rabbit Anti-CYPB Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002713

Western Blot (WB) of anti-CYPB antibody

Western Blot: Sample: Mouse Cerebrum lysate; Primary Ab: 1ug/ml Rabbit Anti-Mouse CYPB Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)
Rabbit Anti-CYPB Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002713

Western Blot (WB) of anti-CYPB antibody

Western Blot: Sample: Mouse Liver lysate; Primary Ab: 1ug/ml Rabbit Anti-Mouse CYPB Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
Rabbit Anti-CYPB Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002713

Western Blot (WB) of anti-CYPB antibody

Western Blot: Sample: Recombinant protein
Rabbit Anti-CYPB Polyclonal Antibody, Western Blot (WB) – Cat# MBS2002713

Immunohistochemistry (IHC) of anti-CYPB antibody

DAB staining on IHC-P; Samples: Mouse Heart Tissue)
Rabbit Anti-CYPB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002713

Immunohistochemistry (IHC) of anti-CYPB antibody

DAB staining on fromalin fixed paraffin- embedded liver tissue
Rabbit Anti-CYPB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2002713

Other Notes

Small volumes of anti-CYPB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYPB. It may not necessarily be applicable to this product.

NCBI GI #
71774133
NCBI GeneID
19035
NCBI Accession #
NP_035279.2
UniProt Primary Accession #
P24369
UniProt Related Accession #
P24369
GenBank Nucleotide #
NM_011149.2
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase B
NCBI Official Synonym Full Names
peptidylprolyl isomerase B
NCBI Official Symbol
Ppib
NCBI Official Synonym Symbols
Cphn2; Cphn-2; CyP-20b; AA408962; AA553318; AI844835
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase B
UniProt Synonym Protein Names
CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP
Protein Family
Bifunctional cytochrome P450/NADPH--P450 reductase
UniProt Gene Name
Ppib
UniProt Synonym Gene Names
PPIase B; SCYLP
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase B

UniProt Comments for CYPB

PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

Protein type: Chaperone; Cyclophilin; EC 5.2.1.8; Isomerase; RNA-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9|9 C

Cellular Component: endoplasmic reticulum; endoplasmic reticulum chaperone complex; extracellular exosome; focal adhesion; membrane; nucleus; perinuclear region of cytoplasm; smooth endoplasmic reticulum

Molecular Function: isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding; RNA binding; RNA polymerase binding

Biological Process: positive regulation by host of viral process; positive regulation of multicellular organism growth; protein folding; protein peptidyl-prolyl isomerization; protein stabilization
Show more

Research Articles on CYPB

1. These studies demonstrate novel consequences of the indirect regulatory effect of CyPB on collagen hydroxylation, impacting collagen glycosylation, crosslinking and fibrillogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYPB antibody

 Reference Product  PubMed Publications
 Crtap antibody  >23 publications with CYPB and Crtap
 Lepre1 antibody  >21 publications with CYPB and Lepre1
 Serpinh1 antibody  >9 publications with CYPB and Serpinh1
 Pdia3 antibody  >1 publications with CYPB and Pdia3

Pathways associated with anti-CYPB antibody

 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram

Diseases associated with anti-CYPB antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with CYPB and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with CYPB and Brain Diseases
 Breast Neoplasms Antibodies  >2 publications with CYPB and Breast Neoplasms
 Inflammation Antibodies  >2 publications with CYPB and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with CYPB and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >1 publications with CYPB and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >1 publications with CYPB and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with CYPB and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with CYPB and Kidney Diseases
 Heart Diseases Antibodies  >1 publications with CYPB and Heart Diseases

Organs/Tissues associated with anti-CYPB antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with CYPB and Blood
 Skin Antibodies  >12 publications with CYPB and Skin
 Connective Tissue Antibodies  >6 publications with CYPB and Connective Tissue
 Liver Antibodies  >4 publications with CYPB and Liver
 Muscle Antibodies  >4 publications with CYPB and Muscle
 Brain Antibodies  >4 publications with CYPB and Brain
 Kidney Antibodies  >3 publications with CYPB and Kidney
 Heart Antibodies  >3 publications with CYPB and Heart
 Lung Antibodies  >2 publications with CYPB and Lung
 Pancreas Antibodies  >2 publications with CYPB and Pancreas
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000