Selectin, Platelet (SELP) Antibody – Rabbit Polyclonal

SELP: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the selectin/LECAM family.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1 H2.2|1 71.42 cM

Cellular Component: external side of plasma membrane; extracellular space; integral component of membrane; membrane; platelet alpha granule membrane

Molecular Function: calcium ion binding; calcium-dependent protein binding; carbohydrate binding; fucose binding; heparin binding; lipopolysaccharide binding; protein binding; sialic acid binding

Biological Process: cell adhesion; cellular response to interleukin-6; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; inflammatory response; leukocyte adhesion; leukocyte migration; leukocyte tethering or rolling; positive regulation of cell adhesion; positive regulation of leukocyte migration; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of platelet activation; regulation of cellular extravasation; regulation of integrin activation